INT350701

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Context Info
Confidence 0.03
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.46
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) cell adhesion (Cd4)
plasma membrane (Cd4) enzyme binding (Cd4) ligase activity (Mthfd1)
Anatomy Link Frequency
T cells 2
Mthfd1 (Mus musculus)
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 100.00 Very High Very High Very High
Central nervous system 27 99.68 Very High Very High Very High
Multiple sclerosis 158 88.80 High High
Inflammation 28 49.16 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 100.00 Very High Very High Very High
Central Nervous System Disease 27 99.68 Very High Very High Very High
Multiple Sclerosis 20 98.54 Very High Very High Very High
Recurrence 7 94.88 High High
Disease 68 90.96 High High
Demyelinating Disease 175 88.80 High High
Neurodegenerative Disease 10 34.12 Quite Low
Disease Progression 3 14.24 Low Low
Autoimmune Disease 46 5.00 Very Low Very Low Very Low
Repression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DCs can be further subdivided into myeloid (mDCs) and plasmacytoid DCs (pDCs) depending on their lineage, and they also differ in function [163]. pDCs are the major CNS-infiltrating DC population during EAE and pDCs have both stimulatory and regulatory effects on T cells [197]. pDCs negatively regulate CD4+ inflammatory responses in the CNS [197].
pDCs Regulation (regulate) of Gene_expression (responses) of CD4 in T cells associated with multiple sclerosis, inflammatory response and central nervous system
1) Confidence 0.03 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.46 Pain Relevance 0.33

General Comments

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