INT350702

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Context Info
Confidence 0.35
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.56
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Rc3h1) cytoplasm (Rc3h1)
Anatomy Link Frequency
T-cell 2
Rc3h1 (Mus musculus)
Icos (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 54 79.80 Quite High
Inflammation 56 79.40 Quite High
tolerance 10 40.60 Quite Low
Multiple sclerosis 316 5.00 Very Low Very Low Very Low
Central nervous system 54 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 10 97.84 Very High Very High Very High
Systemic Lupus Erythematosus 6 96.84 Very High Very High Very High
Autoimmune Disease 92 87.24 High High
INFLAMMATION 70 79.40 Quite High
Congenital Anomalies 6 77.64 Quite High
Infection 12 68.00 Quite High
Hematological Disease 6 56.00 Quite High
Disease 136 28.16 Quite Low
Targeted Disruption 14 15.28 Low Low
Necrosis 4 9.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normal T cells, Roquin normally limits the expression of inducible T-cell costimulator (ICOS) by promoting the degradation of ICOS mRNA.
Roquin Positive_regulation (promoting) of Protein_catabolism (degradation) of ICOS in T-cell
1) Confidence 0.35 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.77 Pain Relevance 0.08
Yu et al. reported that miR-101 is required for the Roquin-mediated degradation of ICOS mRNA [155].
Roquin Positive_regulation (mediated) of Protein_catabolism (degradation) of ICOS
2) Confidence 0.23 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.79 Pain Relevance 0.10

General Comments

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