INT350718

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Context Info
Confidence 0.00
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Mir106b (Mus musculus)
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 158 86.00 High High
Inflammation 28 55.44 Quite High
tolerance 5 48.28 Quite Low
Central nervous system 27 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 175 86.00 High High
INFLAMMATION 35 55.44 Quite High
Disease 68 54.40 Quite High
Autoimmune Disease 46 49.44 Quite Low
Targeted Disruption 7 31.64 Quite Low
Neurological Disease 1 26.56 Quite Low
Central Nervous System Disease 27 5.00 Very Low Very Low Very Low
Multiple Sclerosis 20 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low
Repression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, in a preliminary experiment performed in a very small number of subjects, the ratio between Treg cells (CD4+CD25+CD127DIM)/T effector cells (CD4+CD25+CD127high) showed an enrichment of these miRNA in Treg cells derived from patients as compared to healthy controls [266]. miR-106b and miR-25 modulate the TGF-beta signaling pathway through their action on cell cycle inhibitor CDKN1A/p21 and the proapoptotic gene BCL2L11/Bim.
miR-106b Regulation (modulate) of TGF-beta
1) Confidence 0.00 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.42 Pain Relevance 0.18

General Comments

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