INT350823

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Context Info
Confidence 0.17
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.75
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1) endoplasmic reticulum (SELS) plasma membrane (SELS)
enzyme binding (SELS) cytoplasm (SELS)
Anatomy Link Frequency
liver 1
SAA1 (Homo sapiens)
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 96.84 Very High Very High Very High
Inflammatory marker 6 36.00 Quite Low
cytokine 8 22.72 Low Low
Angina 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 12 98.20 Very High Very High Very High
Diabetes Mellitus 42 97.88 Very High Very High Very High
Obesity 142 97.16 Very High Very High Very High
INFLAMMATION 16 96.84 Very High Very High Very High
Cardiovascular Disease 10 96.12 Very High Very High Very High
Disorder Of Lipid Metabolism 24 79.88 Quite High
Metabolic Disorder 8 47.28 Quite Low
Increased Venous Pressure Under Development 2 45.04 Quite Low
Hepatocellular Cancer 4 32.20 Quite Low
Metabolic Syndrome 2 15.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been speculated that the interaction between the SAA1 protein and the putative receptor SELS [6] could be involved in the development of insulin resistance, and a recent study in rats showed that the expression level of SELS in liver was higher in diabetic rats compared with both healthy rats and diabetic rats treated with the insulin sensitizer rosiglitazone [25].
SAA1 protein Binding (interaction) of SELS in liver associated with diabetes mellitus and insulin resistance
1) Confidence 0.17 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.46 Pain Relevance 0
SELS, and its interaction with SAA, has been proposed to be a mechanistic link between type 2 diabetes mellitus, inflammation, and cardiovascular disease [6].
SAA Binding (interaction) of SELS associated with inflammation, cardiovascular disease and diabetes mellitus
2) Confidence 0.15 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.29 Pain Relevance 0.05

General Comments

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