INT350833

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Context Info
Confidence 0.61
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.07
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS)
cytoplasm (SELS)
Anatomy Link Frequency
adipocytes 6
hepatocytes 2
adipose tissue 2
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 98.12 Very High Very High Very High
Inflammation 36 77.84 Quite High
Angina 24 63.84 Quite High
Inflammatory marker 18 60.20 Quite High
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 426 99.96 Very High Very High Very High
Diabetes Mellitus 126 99.68 Very High Very High Very High
Insulin Resistance 36 99.32 Very High Very High Very High
Hepatocellular Cancer 12 98.00 Very High Very High Very High
Cancer 6 92.80 High High
Necrosis 6 92.56 High High
Stress 6 90.12 High High
Disorder Of Lipid Metabolism 72 84.24 Quite High
Metabolic Disorder 24 78.92 Quite High
INFLAMMATION 48 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of SELS increased after insulin stimulation in isolated human adipocytes (P = .008).
Positive_regulation (increased) of Gene_expression (expression) of SELS in adipocytes associated with obesity
1) Confidence 0.61 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.30 Pain Relevance 0.16
It has also been shown that SELS expression is inhibited by glucose in cultured hepatocytes and that overexpression of SELS causes a reduction in glucose uptake in cultured hepatoma cells [1,6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SELS in hepatocytes associated with hepatocellular cancer
2) Confidence 0.47 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.07 Pain Relevance 0
The activation of SELS expression is influenced by a promoter polymorphism (rs28665122); and human studies have shown that SELS genotype is associated with circulating levels of proinflammatory cytokines, such as tumor necrosis factor–?
Positive_regulation (activation) of Gene_expression (expression) of SELS associated with necrosis, cancer and cytokine
3) Confidence 0.47 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.06 Pain Relevance 0.13
To further investigate the link between glycemic control and SELS gene expression, we analyzed the effect of insulin stimulation on isolated subcutaneous adipocytes and found that the expression of SELS increased after insulin stimulation (Fig. 1, P = .008).
Positive_regulation (increased) of Gene_expression (expression) of SELS in adipocytes associated with obesity
4) Confidence 0.44 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.91 Pain Relevance 0
SELS expression in insulin-stimulated adipocytes
Positive_regulation (stimulated) of Gene_expression (expression) of SELS in adipocytes associated with obesity
5) Confidence 0.44 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.87 Pain Relevance 0
In omental adipose tissue from diabetic subjects, gene expression of SELS is increased compared with that in nondiabetic controls; and in both groups, SELS expression correlates with homeostasis model assessment of insulin resistance (HOMA-IR) [7].
Positive_regulation (increased) of Gene_expression (expression) of SELS in adipose tissue associated with diabetes mellitus, obesity and insulin resistance
6) Confidence 0.41 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

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