INT350834

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Context Info
Confidence 0.53
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS)
cytoplasm (SELS)
Anatomy Link Frequency
subcutaneous adipose tissue 2
blood 1
epithelial cells 1
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 99.72 Very High Very High Very High
Inflammation 24 74.56 Quite High
Angina 16 5.00 Very Low Very Low Very Low
Inflammatory marker 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 284 99.84 Very High Very High Very High
Diabetes Mellitus 84 96.76 Very High Very High Very High
Disorder Of Lipid Metabolism 48 92.52 High High
Insulin Resistance 24 87.20 High High
Cancer 4 82.32 Quite High
Necrosis 4 81.84 Quite High
Hepatocellular Cancer 8 79.08 Quite High
INFLAMMATION 32 74.56 Quite High
Stress 4 70.20 Quite High
Metabolic Disorder 16 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No correlation was seen between SELS mRNA levels in adipose tissue and glucose, insulin, or blood lipid levels in the study by Karlsson et al [5].
Transcription (levels) of SELS in blood associated with obesity
1) Confidence 0.53 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.19 Pain Relevance 0
Furthermore, we found positive correlations between SELS mRNA levels in subcutaneous adipose tissue and waist circumference, FFM, and systolic and diastolic BP in the lean siblings and positive correlations with BMI, FM, serum levels of triglycerides and HDL cholesterol, insulin, and HOMA-IR in the obese siblings.
Transcription (levels) of SELS in subcutaneous adipose tissue associated with obesity and disorder of lipid metabolism
2) Confidence 0.53 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.33 Pain Relevance 0
In this study, we found positive correlations between SELS mRNA levels in subcutaneous adipose tissue and sagittal diameter in both lean (n = 90) and obese (n = 90) subjects after adjustment for sex and age.
Transcription (levels) of SELS in subcutaneous adipose tissue associated with obesity
3) Confidence 0.53 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.28 Pain Relevance 0
Furthermore, in HepG2 and intestinal epithelial cells, proinflammatory cytokines activate the transcription of SELS [8,9].
Transcription (transcription) of SELS in epithelial cells associated with cytokine
4) Confidence 0.47 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

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