INT350901

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 1.59 Pain Relevance 0

peptidase activity (Pcsk4)

Anatomy Link Frequency A431 1 Pcsk4 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 topical agent 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat T-cell Lymphoma 1 99.50 Squamous Cell Carcinoma 2 99.44 Mycosis Fungoides 17 98.08 Malignant Neoplastic Disease 17 97.22 Sezary Syndrome 14 96.72 Lymphatic System Cancer 11 94.56 Apoptosis 30 93.86 Cancer 7 5.00 Wrinkles 5 5.00 Death 3 5.00

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Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome Our current focus on the effects of Photodynamic Therapy (PDT) using silicon phthalocyanine Pc 4 photosensitizer on malignant T lymphocytes arose due to preclinical observations that Jurkat cells, common surrogate for human T cell lymphoma, were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells.

Positive_regulation (induced) of Pc 4 in A431 associated with squamous cell carcinoma, t-cell lymphoma, malignant neoplastic disease, sezary syndrome, mycosis fungoides and apoptosis

1) Confidence 0.08 Published 2010 Journal Advances in Hematology Section Title Doc Link PMC3004392 Disease Relevance 1.59 Pain Relevance 0

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