INT350931

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.89
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rad23b) cytoplasm (Rad23b)
Anatomy Link Frequency
skin 2
Rad23b (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 2 92.08 High High
dexamethasone 9 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Antiemetics 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 63 98.26 Very High Very High Very High
Sarcoma 3 94.24 High High
Cancer 136 92.28 High High
Stress 2 90.24 High High
Toxicity 43 88.24 High High
Leukemia 23 79.60 Quite High
Apoptosis 14 78.60 Quite High
Cardiovascular Disorder Under Development 5 76.72 Quite High
Targeted Disruption 10 62.48 Quite High
Death 5 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HR23B expression was further investigated in 21 skin biopsies from 20 patients with CTCL enrolled in a Vorinostat Phase II trial [46] and analyzed by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of HR23B in skin associated with lymphatic system cancer
1) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3004414 Disease Relevance 0.75 Pain Relevance 0
An immunohistochemical analysis of a collection of cutaneous T-cell lymphoma (CTCL) skin biopsies obtained from a Vorinostat phase II trial showed a correlation between HR23B expression and clinical response.
Gene_expression (expression) of HR23B in skin associated with lymphatic system cancer
2) Confidence 0.18 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.59 Pain Relevance 0.04
Thus, HR23B expression may serve as a predictive biomarker for HDACi treatment.
Gene_expression (expression) of HR23B
3) Confidence 0.18 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.55 Pain Relevance 0.05

General Comments

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