INT35097

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 26
Disease Relevance 3.86
Pain Relevance 12.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
brain 4
blood 1
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 1743 100.00 Very High Very High Very High
monoamine 273 99.82 Very High Very High Very High
Morphine 20 99.56 Very High Very High Very High
depression 399 99.32 Very High Very High Very High
Antinociceptive 5 97.68 Very High Very High Very High
tolerance 14 97.32 Very High Very High Very High
Acute pain 1 96.64 Very High Very High Very High
agonist 231 96.28 Very High Very High Very High
Potency 21 95.88 Very High Very High Very High
fluoxetine 231 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.44 Very High Very High Very High
Depression 399 99.32 Very High Very High Very High
Heart Rate Under Development 5 97.20 Very High Very High Very High
Arrhythmias 2 Under Development 5 97.04 Very High Very High Very High
Pain 1 96.64 Very High Very High Very High
Affective Disorder 42 94.84 High High
Cv Unclassified Under Development 2 89.24 High High
Disease 63 85.16 High High
Coronary Heart Disease 1 82.64 Quite High
Death 2 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous CDP-choline produced a short-term increase in blood pressure and reduced the incidence of VT, VF, and lethality dose-dependently when injected in the middle of the ischemic period.
Gene_expression (produced) of CDP-choline in blood associated with heart rate under development, pressure and volume under development and arrhythmias 2 under development
1) Confidence 0.58 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18504556 Disease Relevance 1.34 Pain Relevance 0.29
This implies that the compounds do not inhibit IP breakdown (otherwise they would have substituted for Li+), and that their effects on IP accumulation is probably secondary and passive to the enhanced production of upstream CDP-DG and PI substrates.
Gene_expression (production) of CDP
2) Confidence 0.55 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.05 Pain Relevance 0.40
Although CDP-DG production induced by the antidepressants may be derived from phosphoinositide breakdown, it is not impossible that the CDP-DG pool may be generated from additional endogenous sources.
Gene_expression (production) of CDP associated with antidepressant
3) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.63
Brain tissues were prepared and incubated as described above for assaying CDP-DG, except that 1.5 ?
Gene_expression (assaying) of CDP in Brain
4) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0
Conversely, the selective PLC inhibitor U73122 could only partially decrease CDP-DG production, while it completely blocked the release of IPs.
Gene_expression (production) of CDP
5) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.52
Additionally, whereas CDP initially produced only dose-related decreases in DRL and FR response rates, following weekly morphine the smaller doses of CDP (4.0-16.0 mg/kg) produced increases in response rates.
Gene_expression (produced) of CDP associated with morphine
6) Confidence 0.53 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3114785 Disease Relevance 0.06 Pain Relevance 1.03
Additionally, whereas CDP initially produced only dose-related decreases in DRL and FR response rates, following weekly morphine the smaller doses of CDP (4.0-16.0 mg/kg) produced increases in response rates.
Gene_expression (produced) of CDP associated with morphine
7) Confidence 0.53 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3114785 Disease Relevance 0.07 Pain Relevance 1.08
Antidepressants elicit greater stimulation of CDP-diacylglycerol production than IP formation
Gene_expression (production) of CDP associated with antidepressant
8) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.51
With the ultimate goal of uncovering the primary postsynaptic actions that may initiate cellular antidepressive signaling, we have examined the antidepressant-induced production of CDP-diacylglycerol which is both a product of diacylglycerol phosphorylation and a precursor for the synthesis of physiologically critical glycerophospholipids such as the phosphatidylinositides.
Spec (examined) Gene_expression (production) of CDP associated with antidepressant
9) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2245968 Disease Relevance 0.54 Pain Relevance 0.70
The present data demonstrate for the first time that antidepressant agents could increase by several-fold the production of CDP-diacylglycerol, a crucial signaling intermediate that is both a derivative of diacylglycerol and a precursor for the biosynthesis of PIs.
Gene_expression (production) of CDP associated with antidepressant
10) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.48
Hence, to the extent that CDP-DG production might be relevant to depression or the mechanism of antidepressant drug action, an antidepressive agent should not merely increase PI hydrolysis, but the CDP-DG produced must exceed and probably precede the production of PI messengers.
Gene_expression (produced) of CDP associated with antidepressant and depression
11) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.73
Increasing concentrations of neomycin produced complete blockade of both CDP-DG and PI responses.
Gene_expression (produced) of CDP
12) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.38
As shown in Figure 7, LiCl did not significantly enhance or inhibit antidepressant drug-induced CDP-DG production, implying that the presence of Li+ is not necessary to demonstrate the enhancing effects of antidepressant agents on CDP-DG production.


Gene_expression (production) of CDP associated with antidepressant
13) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.49
These results suggest that, while the integrity of the phosphoinositide pool is essential to the full effect of antidepressant agents on CDP-DG (based on the neomycin data), the PLC-accessible pool of phosphoinositides may not be the only source of antidepressant-mediated CDP-DG production (based on the U73122 data).
Gene_expression (production) of CDP associated with antidepressant
14) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.46
M resulted in CDP-DG effects that were either statistically similar to, or significantly lower than, the effects observed at 100 ?
Gene_expression (resulted) of CDP
15) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.58
Effects of monoamine oxidase inhibiting agents CDP-diacylglycerol formation and PI synthesis
Neg (inhibiting) Gene_expression (inhibiting) of CDP associated with monoamine
16) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.56
As shown in Figure 6, U73122 by itself did not significantly alter basal CDP-DG production (Figure 6A) or IP accumulation (Figure 6B), although a slight increase in IP was consistently noted.
Gene_expression (production) of CDP
17) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.05 Pain Relevance 0.40
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Gene_expression (ineffective) of CDP
18) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.22
To test if the antidepressant-enhanced CDP-DG translates into increased synthesis of the PIs, brain slice preparations were labeled with [3H] inositol and incubated in the presence of various antidepressant agents.
Gene_expression (synthesis) of CDP in brain associated with antidepressant
19) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.09 Pain Relevance 0.75
Thus, diverse antidepressant agents can acutely induce CDP-DG synthesis in depression-relevant regions of the rat brain.


Gene_expression (induce) of CDP in brain associated with antidepressant and depression
20) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.69

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