INT35098

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
spinal 1
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 3 99.96 Very High Very High Very High
Antinociceptive 4 99.30 Very High Very High Very High
antinociception 1 96.96 Very High Very High Very High
tail-flick 2 88.76 High High
tolerance 2 83.92 Quite High
agonist 1 80.96 Quite High
intrathecal 2 75.00 Quite High
Pain 2 25.00 Low Low
nociceptor 1 25.00 Low Low
antagonist 1 18.56 Low Low
Disease Link Frequency Relevance Heat
Calcification 46 100.00 Very High Very High Very High
Osteoporosis 8 86.80 High High
Metastasis 58 80.32 Quite High
Adhesions 1 76.92 Quite High
Breast Cancer 46 70.96 Quite High
Advanced Or Metastatic Breast Cancer 1 53.52 Quite High
Cancer 68 50.00 Quite Low
Targeted Disruption 5 31.48 Quite Low
Hepatocellular Cancer 1 28.84 Quite Low
Thyroid Neoplasm 1 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPP1 and ANK in PPi metabolism and calcification
Localization (calcification) of NPP1 associated with calcification
1) Confidence 0.75 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0
It is concluded that PCA given intrathecally releases serotonin from spinal terminals, which may under certain conditions induce antinociception.
Localization (releases) of PCA in spinal associated with antinociception and serotonin
2) Confidence 0.62 Published 1985 Journal Acta Physiol. Scand. Section Abstract Doc Link 3155890 Disease Relevance 0 Pain Relevance 0.47
In addition, the antinociceptive effect of the 5-hydroxytryptamine releasing compound p-chloramphetamine (PCA) was reduced following chronic treatment with metergoline.
Localization (releasing) of PCA associated with antinociceptive
3) Confidence 0.62 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3114810 Disease Relevance 0 Pain Relevance 0.21
The expression of autotaxin as a secreted protein and NPP1 as a membrane-bound protein were confirmed by western blotting using specific antibodies (Figure 1A).
Localization (secreted) of NPP1
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.32 Pain Relevance 0

General Comments

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