INT35098

Context Info Confidence 0.75 First Reported 1985 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.81 Pain Relevance 0.67

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)

Anatomy Link Frequency spinal 1 Enpp1 (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 3 99.96 Antinociceptive 4 99.30 antinociception 1 96.96 tail-flick 2 88.76 tolerance 2 83.92 agonist 1 80.96 intrathecal 2 75.00 Pain 2 25.00 nociceptor 1 25.00 antagonist 1 18.56

Disease Link Frequency Relevance Heat Calcification 46 100.00 Osteoporosis 8 86.80 Metastasis 58 80.32 Adhesions 1 76.92 Breast Cancer 46 70.96 Advanced Or Metastatic Breast Cancer 1 53.52 Cancer 68 50.00 Targeted Disruption 5 31.48 Hepatocellular Cancer 1 28.84 Thyroid Neoplasm 1 27.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NPP1 and ANK in PPi metabolism and calcification

Localization (calcification) of NPP1 associated with calcification

1) Confidence 0.75 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0

It is concluded that PCA given intrathecally releases serotonin from spinal terminals, which may under certain conditions induce antinociception.

Localization (releases) of PCA in spinal associated with antinociception and serotonin

2) Confidence 0.62 Published 1985 Journal Acta Physiol. Scand. Section Abstract Doc Link 3155890 Disease Relevance 0 Pain Relevance 0.47

In addition, the antinociceptive effect of the 5-hydroxytryptamine releasing compound p-chloramphetamine (PCA) was reduced following chronic treatment with metergoline.

Localization (releasing) of PCA associated with antinociceptive

3) Confidence 0.62 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3114810 Disease Relevance 0 Pain Relevance 0.21

The expression of autotaxin as a secreted protein and NPP1 as a membrane-bound protein were confirmed by western blotting using specific antibodies (Figure 1A).

Localization (secreted) of NPP1

4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.32 Pain Relevance 0

General Comments

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