INT350981

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VHL, XRCC1) nucleoplasm (XRCC1) mitochondrion (VHL)
cell morphogenesis (VHL) endoplasmic reticulum (VHL) intracellular (XRCC1)
VHL (Homo sapiens)
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 24.56 Low Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 63 100.00 Very High Very High Very High
Cancer 34 98.68 Very High Very High Very High
Disease 8 89.16 High High
Proteinuria 11 83.88 Quite High
Toxicity 28 82.08 Quite High
Renal Insufficiency 1 61.64 Quite High
Hypertension 12 56.48 Quite High
Exanthema 4 55.68 Quite High
Diarrhoea 6 54.72 Quite High
Carcinoma 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is a VHL-regulated growth factor for RCC, with biologic effects mediated through EGFR.38 In view of these observations, a phase 2 clinical trial in metastatic RCC with bevacizumab 10 mg/kg IV every 2 weeks in combination with erlotinib 150 mg daily was conducted.39 A 25% objective response rate and 61% stable disease rate was noted with many of the stable disease patients experiencing minor tumor regression.
VHL Regulation (regulated) of RCC associated with cancer, renal cancer and disease
1) Confidence 0.01 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.42 Pain Relevance 0

General Comments

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