INT350984

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VHL, VEGFA) mitochondrion (VHL) cell morphogenesis (VHL)
endoplasmic reticulum (VHL) extracellular matrix organization (VHL) response to stress (VHL)
VHL (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 68 100.00 Very High Very High Very High
Hypoxia 14 100.00 Very High Very High Very High
Renal Cancer 126 99.92 Very High Very High Very High
Carcinoma 18 93.40 High High
Metastasis 12 68.96 Quite High
Solid Tumor 10 40.52 Quite Low
Toxicity 56 5.00 Very Low Very Low Very Low
Hypertension 24 5.00 Very Low Very Low Very Low
Proteinuria 22 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the hypoxia response pathway by mutations of the von Hippel-Lindau (VHL) tumor suppressor gene produces transcriptional activation of genes important in tumor progression, including vascular endothelial growth factor (VEGF), a potent promoter of tumor-associated angiogenesis.2,7 The VHL gene encodes a 213 amino acid protein (pVHL) which functionally regulates the normal cellular response to oxygen deprivation.
Positive_regulation (Activation) of VHL Positive_regulation (activation) of vascular endothelial growth factor associated with cancer and hypoxia
1) Confidence 0.27 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.37 Pain Relevance 0
Activation of the hypoxia response pathway by mutations of the von Hippel-Lindau (VHL) tumor suppressor gene produces transcriptional activation of genes important in tumor progression, including vascular endothelial growth factor (VEGF), a potent promoter of tumor-associated angiogenesis.2,7 The VHL gene encodes a 213 amino acid protein (pVHL) which functionally regulates the normal cellular response to oxygen deprivation.
Positive_regulation (Activation) of VHL Positive_regulation (activation) of VEGF associated with cancer and hypoxia
2) Confidence 0.27 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.37 Pain Relevance 0

General Comments

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