INT351010

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0.05

nucleoplasm (ISG20) intracellular (ISG20) cell-cell signaling (IL2) cell proliferation (ISG20) extracellular space (IL2) extracellular region (IL2)

Anatomy Link Frequency IL2R 2 ISG20 (Homo sapiens) IL2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 99.56 pruritus 4 5.00 Paracetamol 3 5.00 Pain 2 5.00 Antihistamine 2 5.00 dexamethasone 1 5.00 depression 1 5.00 vincristine 1 5.00 tolerance 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Death 3 74.76 Diphtheria 7 67.36 Lymphatic System Cancer 39 66.96 Leukemia 4 64.80 Htlv Types I And Ii 3 61.52 Disease 20 59.04 Immunodeficiency 1 26.16 Malignant Neoplastic Disease 5 22.32 Syndrome 12 5.56 Mycosis Fungoides 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

We know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14

CD25 Positive_regulation (participates) of Transcription (transduction) of IL2 in IL2R associated with cytokine

1) Confidence 0.31 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.46 Pain Relevance 0.05

General Comments

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