INT351013

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0

cell proliferation (ISG20) nucleoplasm (ISG20) extracellular region (PROK1) RNA binding (ISG20) nucleus (ISG20) intracellular (ISG20)

Anatomy Link Frequency T-cells 1 PROK1 (Homo sapiens) ISG20 (Homo sapiens)

Pain Link Frequency Relevance Heat pruritus 4 5.00 cytokine 3 5.00 Paracetamol 3 5.00 Pain 2 5.00 Antihistamine 2 5.00 dexamethasone 1 5.00 depression 1 5.00 vincristine 1 5.00 tolerance 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Diphtheria 7 100.00 Disease 20 99.44 Lymphoproliferative Disease 1 94.88 Lymphatic System Cancer 39 93.36 Malignant Neoplastic Disease 5 88.16 Mycosis Fungoides 12 5.00 Syndrome 12 5.00 Vomiting 6 5.00 Cancer 6 5.00 Leukemia 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

This fusion protein toxin combines the IL2 protein with diphtheria toxin, and targets the CD25 subunit of the IL2 receptor, resulting in the unique delivery of a cytocidal agent to CD-25 bearing T-cells.

protein toxin Regulation (targets) of CD25 in T-cells associated with diphtheria

1) Confidence 0.01 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004568 Disease Relevance 0.76 Pain Relevance 0

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