INT351029

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) mitochondrion (AGK) growth (VEGFA)
extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
AGK (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 111 99.50 Very High Very High Very High
Cancer 40 90.64 High High
Melanoma 17 78.64 Quite High
Malignant Neoplastic Disease 1 65.60 Quite High
Disease 37 17.60 Low Low
Glioma 1 9.76 Low Low
Metastasis 44 5.00 Very Low Very Low Very Low
Recurrence 24 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initial trials of RAF inhibitors in melanoma focused on sorafenib, a multi-kinase inhibitor targeting RAF, VEGF, and PDGF receptor tyrosine kinase signaling.133 However, a phase III trial comparing carboplatin and paclitaxel with and without sorafenib showed no differences between the two treatment groups with respect to the rate of objective tumor response, progression-free survival, and overall survival.117 PLX4032 is a novel tyrosine kinase inhibitor engineered to have a high degree of specificity for mutant BRAFV600E.
multi-kinase Regulation (targeting) of VEGF associated with cancer and skin cancer
1) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004577 Disease Relevance 0.82 Pain Relevance 0

General Comments

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