INT35103

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Context Info
Confidence 0.12
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.51
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
skeletal muscle 4
brain 1
kidney 1
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 91.44 High High
Arthritis 5 90.68 High High
depression 1 89.60 High High
Gabapentin 14 89.28 High High
fibrosis 1 88.08 High High
corticosteroid 4 86.12 High High
methotrexate 43 82.72 Quite High
imagery 4 80.28 Quite High
Leflunomide 1 76.56 Quite High
alcohol 7 74.00 Quite High
Disease Link Frequency Relevance Heat
Hyperbilirubinemia 2 100.00 Very High Very High Very High
Injury 7 99.86 Very High Very High Very High
Dengue 213 99.38 Very High Very High Very High
Congenital Anomalies 12 98.04 Very High Very High Very High
Liver Disease 7 97.72 Very High Very High Very High
Hepatotoxicity 29 94.16 High High
Hepatitis C Virus Infection 22 91.04 High High
Infectious Arthritis 5 90.68 High High
Depression 1 89.60 High High
Pulmonary Fibrosis 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most frequent abnormal LFT was elevated ALT (36.7%), followed by elevated alkaline phosphatase (16.9%), hyperbilirubinemia (9.6%) and elevated AST (9.0%).
Positive_regulation (elevated) of Positive_regulation (elevated) of AST associated with hyperbilirubinemia
1) Confidence 0.12 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902446 Disease Relevance 0.89 Pain Relevance 0.23
Results of ALT and AST were minimally elevated in 1 and 4 patients respectively with the highest value being an ALT of 86 in patient #6 (data not shown in table) while LDH was elevated in 10 patients.
Positive_regulation (elevated) of Positive_regulation (elevated) of AST
2) Confidence 0.12 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1885437 Disease Relevance 1.73 Pain Relevance 0.28
In serial studies, diminution in Gc level preceded the rise in AST and increase in the percent complexed.
Positive_regulation (rise) of Positive_regulation (increase) of AST
3) Confidence 0.10 Published 1987 Journal Hepatology Section Abstract Doc Link 3115882 Disease Relevance 0.58 Pain Relevance 0.37
Alanine aminotransferase is primarily associated with hepatocytes, with minimal activity in cardiac and skeletal muscle, and AST is found in erythrocytes, cardiac and skeletal muscle, and kidney and brain tissue, and is often elevated because of damage to those sources and in response to hepatic damage.26 Given the prominence of musculoskeletal symptoms among adults with dengue, skeletal muscle injury could contribute to the elevation in AST levels.
Positive_regulation (contribute) of Positive_regulation (elevation) of AST in skeletal muscle associated with injury and dengue
4) Confidence 0.06 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.10 Pain Relevance 0
Patients were excluded if they had functional class IV using SteinbrockerÂ’s criteria [10], aspartate transaminase (AST), alanine transaminase (ALT) and serum creatinine ?
Positive_regulation (using) of Positive_regulation (aspartate) of AST
5) Confidence 0.06 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638601 Disease Relevance 1.03 Pain Relevance 0.37
Alanine aminotransferase is primarily associated with hepatocytes, with minimal activity in cardiac and skeletal muscle, and AST is found in erythrocytes, cardiac and skeletal muscle, and kidney and brain tissue, and is often elevated because of damage to those sources and in response to hepatic damage.26 Given the prominence of musculoskeletal symptoms among adults with dengue, skeletal muscle injury could contribute to the elevation in AST levels.
Positive_regulation (contribute) of in brain Positive_regulation (elevation) of AST in skeletal muscle associated with injury and dengue
6) Confidence 0.02 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.10 Pain Relevance 0
Alanine aminotransferase is primarily associated with hepatocytes, with minimal activity in cardiac and skeletal muscle, and AST is found in erythrocytes, cardiac and skeletal muscle, and kidney and brain tissue, and is often elevated because of damage to those sources and in response to hepatic damage.26 Given the prominence of musculoskeletal symptoms among adults with dengue, skeletal muscle injury could contribute to the elevation in AST levels.
Positive_regulation (contribute) of in kidney Positive_regulation (elevation) of AST in skeletal muscle associated with injury and dengue
7) Confidence 0.02 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.10 Pain Relevance 0

General Comments

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