INT35104

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Context Info
Confidence 0.11
First Reported 1987
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.99
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GC) extracellular space (GC) small molecule metabolic process (GC)
extracellular region (GC)
Anatomy Link Frequency
plasma 2
lymph node 1
liver 1
GC (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 99.84 Very High Very High Very High
Codeine 11 99.58 Very High Very High Very High
Bioavailability 2 97.84 Very High Very High Very High
Paracetamol 5 86.48 High High
corticosteroid 1 78.88 Quite High
addiction 3 67.44 Quite High
headache 1 65.56 Quite High
depression 2 46.32 Quite Low
anticonvulsant 2 37.48 Quite Low
cINOD 9 29.04 Quite Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 98.74 Very High Very High Very High
Sickle Cell Anemia 7 98.20 Very High Very High Very High
Disease 42 97.76 Very High Very High Very High
Necrosis 8 97.00 Very High Very High Very High
Syndrome 8 92.68 High High
Prostate Cancer 101 90.64 High High
Pneumocystis Carinii Infection 1 90.16 High High
Injury 2 87.44 High High
Adenoma 1 87.36 High High
Metastasis 15 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased complexing of circulating group-specific component (Gc, vitamin D-binding protein) has been found in humans under conditions of presumed increased actin release, and particularly fulminant hepatic necrosis (FHN).
Positive_regulation (circulating) of vitamin D-binding protein associated with necrosis
1) Confidence 0.11 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3598340 Disease Relevance 0.62 Pain Relevance 0.09
Evidence for increased plasma levels of complexes containing Gc (vitamin D-binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man.
Positive_regulation (increased) of vitamin D-binding protein in plasma associated with necrosis
2) Confidence 0.10 Published 1987 Journal Hepatology Section Abstract Doc Link 3115882 Disease Relevance 0.26 Pain Relevance 0.16
Serum sex hormone binding globulin was elevated.
Positive_regulation (elevated) of globulin
3) Confidence 0.05 Published 2003 Journal South. Med. J. Section Abstract Doc Link 14513996 Disease Relevance 0.99 Pain Relevance 0.12
Codeine is known to bind to gamma-globulin, a fact that may explain in part the observed increase in the plasma protein binding of codeine in sickle cell patients.
Spec (observed) Positive_regulation (increase) of gamma-globulin in plasma associated with sickle cell anemia and codeine
4) Confidence 0.04 Published 1993 Journal J Pharm Sci Section Abstract Doc Link 8289123 Disease Relevance 0.47 Pain Relevance 0.63
The patient had just had a liver transplant and had received antithymocyte globulin as part of his immunosuppressive induction.
Positive_regulation (induction) of globulin in liver
5) Confidence 0.01 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 0.98 Pain Relevance 0.04
In a retrospective cohort study of nearly 450 patients, Sywak et al have demonstrated that, in PTC, the addition of routine central lymph node dissection (CLND) results in lower postablation thyro-globulin levels and potentially reduces recurrent or persistent disease and avoids reoperative surgery.
Positive_regulation (results) of thyro-globulin in lymph node associated with thyroid neoplasm and disease
6) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.96 Pain Relevance 0
Phytoestrogens found in soy products increase serum sex hormone binding globulin via increased hepatic synthesis which then decreases bioavailability of testosterone.
Positive_regulation (increase) of globulin associated with bioavailability
7) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684344 Disease Relevance 0.71 Pain Relevance 0.05

General Comments

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