INT351076

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp3) mitochondrion (Ucp3) extracellular space (IK)
nucleus (IK) transmembrane transport (Ucp3) cell-cell signaling (IK)
Anatomy Link Frequency
muscle 2
IK (Homo sapiens)
Ucp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
Inflammation 8 94.80 High High
Etanercept 2 72.24 Quite High
antagonist 6 58.32 Quite High
agonist 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Cannabinoid 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 9 97.00 Very High Very High Very High
Cancer 73 96.12 Very High Very High Very High
Appetite Loss 94 95.84 Very High Very High Very High
INFLAMMATION 9 94.80 High High
Syndrome 9 88.92 High High
Fatigue 2 74.72 Quite High
Lewis Lung Carcinoma 1 53.32 Quite High
Pressure And Volume Under Development 3 48.64 Quite Low
Adenocarcinoma 3 47.52 Quite Low
Toxicity 7 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-15 has been reported to be an anabolic factor for skeletal muscle.49 This cytokine is able to decrease protein degradation, decrease the rate of DNA fragmentation and increase UCP3 expression in skeletal muscle, these being the most important trends associated with muscle wasting during cancer cachexia.50,51 In vitro experiments carried out using both isolated incubated muscle and muscle cells in culture corroborate the in vivo observations indicating a direct action of the cytokine upon skeletal muscle.52 Although no clinical data are available, treatment of cachectic experimental animals with IL-15 leads to an improvement of muscle mass and performance.50


Other therapeutic approaches

Anabolic steroids

cytokine Positive_regulation (increase) of Gene_expression (expression) of UCP3 in muscle associated with appetite loss, cancer, frailty and cytokine
1) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 0.80 Pain Relevance 0.58

General Comments

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