INT351085

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0

plasma membrane (EGFR, TXK) nucleus (EGFR, TXK) cytoplasm (EGFR, TXK) DNA binding (TXK) extracellular space (EGFR) endosome (EGFR)

EGFR (Homo sapiens) TXK (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 21 5.00 cva 3 5.00 Pain 2 5.00 Bioavailability 2 5.00 addiction 2 5.00 tolerance 2 5.00 palliative 1 5.00 carbamazepine 1 5.00 dexamethasone 1 5.00 opiate 1 5.00

Disease Link Frequency Relevance Heat Advanced Or Metastatic Breast Cancer 28 91.20 Cancer 35 64.80 Breast Cancer 16 59.76 Disease 45 22.68 Toxicity 12 15.84 Death 5 14.80 Diarrhoea 25 5.00 Exanthema 19 5.00 Metastasis 16 5.00 Vomiting 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ligand binding of these ErbB receptors causes formation of heterodimers or homodimers, in turn inducing autophosphorylation of specific tyrosine kinase residues within conserved catalytic domains of the ErbB receptors.

ErbB Binding (binding) of Positive_regulation (inducing) of Phosphorylation (autophosphorylation) of tyrosine kinase

1) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.35 Pain Relevance 0

General Comments

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