INT351086

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.19

cytoplasm (ERBB2, ESR1) signal transduction (ERBB2, ESR1) nucleus (ERBB2, ESR1) plasma membrane (ERBB2, ESR1) nucleoplasm (ESR1) enzyme binding (ESR1)

ERBB2 (Homo sapiens) ESR1 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 73.04 Pain 2 61.28 Central nervous system 21 5.00 cva 3 5.00 Bioavailability 2 5.00 addiction 2 5.00 tolerance 2 5.00 carbamazepine 1 5.00 dexamethasone 1 5.00 opiate 1 5.00

Disease Link Frequency Relevance Heat Cancer 35 96.56 Breast Cancer 16 89.24 Disease 45 76.16 Pain 2 61.28 Anxiety Disorder 1 55.04 Appetite Loss 3 54.32 Fatigue 3 53.28 Advanced Or Metastatic Breast Cancer 28 30.16 Toxicity 12 15.48 Death 5 14.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Prolonged inhibition of ErbB2 kinase activity resulted in upregulation of the transcription factor FOXO3A which upregulates estrogen receptor (ER) expression and signaling.

Negative_regulation (inhibition) of ErbB2 Positive_regulation (upregulates) of Gene_expression (expression) of ER

1) Confidence 0.10 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.75 Pain Relevance 0.19

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