INT351088

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ERBB2, FOXO3) nucleus (ERBB2, FOXO3) nucleoplasm (FOXO3)
embryo development (FOXO3) DNA binding (FOXO3) response to stress (FOXO3)
ERBB2 (Homo sapiens)
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 68.88 Quite High
Pain 2 57.12 Quite High
Central nervous system 21 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 35 92.40 High High
Breast Cancer 16 89.24 High High
Disease 45 72.00 Quite High
Pain 2 57.12 Quite High
Anxiety Disorder 1 50.88 Quite High
Appetite Loss 3 50.16 Quite High
Fatigue 3 49.12 Quite Low
Advanced Or Metastatic Breast Cancer 28 30.16 Quite Low
Toxicity 12 15.48 Low Low
Death 5 14.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged inhibition of ErbB2 kinase activity resulted in upregulation of the transcription factor FOXO3A which upregulates estrogen receptor (ER) expression and signaling.
Negative_regulation (inhibition) of ErbB2 Positive_regulation (upregulation) of FOXO3A
1) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.66 Pain Relevance 0.18

General Comments

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