INT351089

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3, ESR1) DNA binding (FOXO3, ESR1) cytoplasm (FOXO3, ESR1)
nucleus (FOXO3, ESR1) transcription factor binding (FOXO3, ESR1) enzyme binding (ESR1)
FOXO3 (Homo sapiens)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 73.04 Quite High
Pain 2 61.28 Quite High
Central nervous system 21 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 35 96.56 Very High Very High Very High
Breast Cancer 16 85.68 High High
Disease 45 76.16 Quite High
Pain 2 61.28 Quite High
Anxiety Disorder 1 55.04 Quite High
Appetite Loss 3 54.32 Quite High
Fatigue 3 53.28 Quite High
Advanced Or Metastatic Breast Cancer 28 26.60 Quite Low
Toxicity 12 11.92 Low Low
Death 5 10.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged inhibition of ErbB2 kinase activity resulted in upregulation of the transcription factor FOXO3A which upregulates estrogen receptor (ER) expression and signaling.
FOXO3A Positive_regulation (upregulates) of Gene_expression (expression) of ER
1) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.74 Pain Relevance 0.19

General Comments

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