INT351090

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TXK, EGFR) plasma membrane (TXK, EGFR) cytoplasm (TXK, EGFR)
DNA binding (TXK) extracellular space (EGFR) endosome (EGFR)
TXK (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 21 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 28 82.72 Quite High
Cancer 35 65.60 Quite High
Breast Cancer 16 51.28 Quite High
Disease 45 17.20 Low Low
Toxicity 12 7.36 Low Low
Death 5 6.32 Low Low
Diarrhoea 25 5.00 Very Low Very Low Very Low
Exanthema 19 5.00 Very Low Very Low Very Low
Metastasis 16 5.00 Very Low Very Low Very Low
Vomiting 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosine kinase autophosphorylation establishes binding sites for Src-homology 2 and phosphotyrosine binding domain containing proteins, linking ErbB to activation of downstream intracellular pathways of cell proliferation (mitogen-activated protein kinase (MAPK) pathway) and cell survival (the phosphotidylinositol-3-kinase (PI3K) pathway).
Phosphorylation (autophosphorylation) of Tyrosine kinase Positive_regulation (linking) of ErbB
1) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.33 Pain Relevance 0

General Comments

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