INT351091

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 18.16 Pain 2 6.40 Central nervous system 21 5.00 cva 3 5.00 Bioavailability 2 5.00 addiction 2 5.00 tolerance 2 5.00 carbamazepine 1 5.00 dexamethasone 1 5.00 opiate 1 5.00

Disease Link Frequency Relevance Heat Cancer 35 97.88 Breast Cancer 16 79.44 Advanced Or Metastatic Breast Cancer 28 52.68 Toxicity 12 38.00 Death 5 36.88 Hepatotoxicity 1 23.28 Disease 45 21.28 Cv Unclassified Under Development 2 16.48 Diarrhoea 25 12.28 Exanthema 19 9.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PTEN loss is associated with a lower response to trastuzumab, however lapatinib appears PTEN independent and seems to maintain activity despite loss of this tumor suppressor.42,43

Spec (appears) Negative_regulation (appears) of PTEN Binding (independent) of associated with cancer

1) Confidence 0.09 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.23 Pain Relevance 0

General Comments

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