INT351097

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4EBP1) signal transduction (RRAD) nucleus (EIF4EBP1)
plasma membrane (RRAD) translation (EIF4EBP1) GTPase activity (RRAD)
Anatomy Link Frequency
PBMC 1
RRAD (Homo sapiens)
EIF4EBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 20 40.48 Quite Low
Carcinoma 4 40.32 Quite Low
Renal Cell Carcinoma 29 39.16 Quite Low
Solid Tumor 4 26.32 Quite Low
Death 2 14.20 Low Low
Pneumonia 16 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Stomatitis 8 5.00 Very Low Very Low Very Low
Metastasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preclinical ex-vivo experiments have demonstrated that peripheral blood mononuclear cell (PBMC)-derived 4E-BP1 was unaffected by a suboptimal RAD001 dose despite transient effects on S6K1 activity, suggesting that S6K1 is a more sensitive marker of everolimus exposure in PBMCs than 4E-BP1.
RAD001 Neg (unaffected) Negative_regulation (unaffected) of 4E-BP1 in PBMC
1) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0 Pain Relevance 0

General Comments

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