INT351112

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)

EIF4E (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 2 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Carcinoma 4 82.36 Renal Cell Carcinoma 29 81.20 Death 2 56.24 Metastasis 7 46.48 Cancer 20 40.24 Pneumonia 16 5.00 Disease 13 5.00 Toxicity 10 5.00 Stomatitis 8 5.00 Fatigue 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The everolimus-FKBP12 complex binds to mTOR and reduces the activity of the downstream effectors S6 ribosomal protein kinase (S6K1) and translational repressor protein eukaryotic elongation factor 4E-binding protein (4EBP).19 eIF-4F activation results in the translation of a subset of capped mRNA containing highly structured 5?

Positive_regulation (results) of Positive_regulation (activation) of eIF-4F

1) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.22 Pain Relevance 0

General Comments

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