INT351116

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMC4) nucleoplasm (PSMC4) mitochondrion (PSMC4)
small molecule metabolic process (PSMC4) nucleolus (PSMC4) ATPase activity (PSMC4)
PSMC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 4 48.08 Quite Low
Renal Cell Carcinoma 29 46.92 Quite Low
Cancer 20 24.00 Low Low
Death 2 21.96 Low Low
Metastasis 7 12.20 Low Low
Solid Tumor 4 9.84 Low Low
Pneumonia 16 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Stomatitis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of S6K1 itself is also tightly regulated by hierarchical phosphorylation events, which are dependent on the activation of various signal transduction pathways and culminate in the phosphorylation of the rapamycin-sensitive site Thr389.32,33 Hence, reductions in S6 phosphorylation by everolimus is expected to parallel S6K1 inactivation.
Negative_regulation (reductions) of Phosphorylation (phosphorylation) of S6
1) Confidence 0.12 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0 Pain Relevance 0

General Comments

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