INT351119

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMC4) nucleoplasm (PSMC4) mitochondrion (PSMC4)
small molecule metabolic process (PSMC4) nucleolus (PSMC4) ATPase activity (PSMC4)
Anatomy Link Frequency
skin 1
PSMC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 99.04 Very High Very High Very High
Toxicity 20 94.92 High High
Solid Tumor 8 88.96 High High
Disorders Of Creatine Metabolism 2 74.92 Quite High
Stomatitis 16 58.00 Quite High
Neutropenia 2 57.04 Quite High
Hyperglycemia 8 55.76 Quite High
Carcinoma 8 47.52 Quite Low
Renal Cell Carcinoma 58 46.36 Quite Low
Metastasis 14 33.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of S6K1 itself is also tightly regulated by hierarchical phosphorylation events, which are dependent on the activation of various signal transduction pathways and culminate in the phosphorylation of the rapamycin-sensitive site Thr389.32,33 Hence, reductions in S6 phosphorylation by everolimus is expected to parallel S6K1 inactivation.
Phosphorylation (phosphorylation) of S6
1) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0 Pain Relevance 0
Pre- and on-treatment steady-state tumor and skin biopsies were evaluated for total and phosphorylated (p) protein S6 kinase 1, eukaryotic initiation factor 4E (eIF-4E) binding protein 1(4E-BP1), eukaryotic initiation factor 4G (eIF-4G), AKT and Ki-67 expression.
Phosphorylation (phosphorylated) of S6 in skin associated with cancer
2) Confidence 0.15 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.92 Pain Relevance 0

General Comments

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