INT351164

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CAV1, Ppp1cc) protein complex (CAV1, Ppp1cc) cytoplasm (CAV1, Ppp1cc)
endosome (CAV1) small molecule metabolic process (CAV1) Golgi apparatus (CAV1)
CAV1 (Homo sapiens)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 198 99.96 Very High Very High Very High
Cancer 174 97.16 Very High Very High Very High
Apoptosis 8 84.24 Quite High
Hyperplasia 2 83.80 Quite High
Disease 98 78.56 Quite High
Repression 2 57.12 Quite High
Metastasis 30 24.28 Low Low
Recurrence 38 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 16 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cav-1-mediated inhibition of PP1 and PP2A results in constitutive activation of prosurvival Akt-signaling.
Cav-1 Negative_regulation (inhibition) of PP1
1) Confidence 0.11 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.75 Pain Relevance 0
In prostate cancer, Cav-1 interacts with and inhibits the serine/threonine protein phosphatases PP1 and PP2A in a CSD-dependent manner.90 PP1 and PP2A are two major classes of phosphatases that act as tumor suppressors by maintaining Akt in a dephosphorylated, inactive state.
Cav-1 Negative_regulation (inhibits) of PP1 associated with cancer and prostate cancer
2) Confidence 0.11 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.75 Pain Relevance 0

General Comments

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