INT35120

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 68
Total Number 73
Disease Relevance 21.33
Pain Relevance 13.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
liver 5
plasma 4
lens 2
hepatocytes 2
muscle 2
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 448 99.98 Very High Very High Very High
cerebral cortex 12 99.84 Very High Very High Very High
Sciatic nerve 33 99.76 Very High Very High Very High
cocaine 11 99.72 Very High Very High Very High
fluoxetine 6 99.68 Very High Very High Very High
dexamethasone 37 99.64 Very High Very High Very High
Codeine 12 99.56 Very High Very High Very High
Hippocampus 15 99.16 Very High Very High Very High
ischemia 174 99.10 Very High Very High Very High
medulla 11 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 100.00 Very High Very High Very High
Hypotension 36 99.76 Very High Very High Very High
Injury 284 99.72 Very High Very High Very High
Stress 312 99.66 Very High Very High Very High
Cv Unclassified Under Development 143 99.10 Very High Very High Very High
Disease 83 99.04 Very High Very High Very High
Edema 12 99.00 Very High Very High Very High
Hepatotoxicity 67 98.88 Very High Very High Very High
Fibrosarcoma 4 98.88 Very High Very High Very High
Cv General 4 Under Development 33 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers.
Gene_expression (production) of MDA associated with codeine, cocaine and morphine
1) Confidence 0.67 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.71
The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers.
Gene_expression (production) of MDA associated with codeine, cocaine and morphine
2) Confidence 0.67 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.69
However, our results revealed that MDA also produced a loss of 5-HT fibers in brainstem that was as severe as that seen in any region of forebrain.
Gene_expression (produced) of MDA in brainstem associated with medulla
3) Confidence 0.67 Published 1993 Journal Brain Res. Section Abstract Doc Link 7690669 Disease Relevance 0 Pain Relevance 0.39
In agreement with previous reports, MDA produced a pronounced loss of 5-HT immunoreactivity in the forebrain, most notably in neocortex and hippocampus.
Gene_expression (produced) of MDA in forebrain associated with hippocampus
4) Confidence 0.59 Published 1993 Journal Brain Res. Section Abstract Doc Link 7690669 Disease Relevance 0 Pain Relevance 0.30
The peritoneal tissues were harvested to determine the tissue levels of MDA, GSH, and NO activity.
Spec (determine) Gene_expression (levels) of MDA
5) Confidence 0.57 Published 2006 Journal Cell Biochem. Funct. Section Abstract Doc Link 15991262 Disease Relevance 0.75 Pain Relevance 0.10
Lipid peroxidation was indexed mainly by assaying the extent of malonaldehyle (MDA) production and also the formation of fluorescent products in the course of the reaction.
Gene_expression (production) of MDA
6) Confidence 0.52 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.68
In the AG-treated rats, tissue levels of MDA and NO were significantly lower than in the control group (p < 0.017).
Gene_expression (levels) of MDA
7) Confidence 0.49 Published 2006 Journal Cell Biochem. Funct. Section Abstract Doc Link 15991262 Disease Relevance 0.71 Pain Relevance 0.10
Some of the beta-aminoxypropionic acids were evaluated for their capacity to inhibit the cyclooxygenase enzyme by measuring the malondialdehyde (MDA) produced by incubation of sodium arachidonate with platelet-rich plasma (PRP).
Gene_expression (produced) of MDA in platelet
8) Confidence 0.34 Published 1994 Journal Farmaco Section Abstract Doc Link 7893333 Disease Relevance 0.33 Pain Relevance 0.21
The three non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone, given 1 h before challenge, significantly inhibited LAC and plasma MDA levels at 4 h post challenge.
Gene_expression (levels) of plasma MDA in plasma associated with inflammation and cinod
9) Confidence 0.30 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 3117715 Disease Relevance 0.63 Pain Relevance 0.35
The standard curve of MDA was constructed over the concentration range of 0–40 ?
Gene_expression (curve) of MDA
10) Confidence 0.30 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0 Pain Relevance 0
Significant reversal of biochemical alterations (peroxynitrite, MDA and NAD levels) were also observed, as well as PAR accumulation in the sciatic nerve.
Gene_expression (levels) of MDA in sciatic nerve associated with sciatic nerve
11) Confidence 0.22 Published 2009 Journal Free Radic. Res. Section Abstract Doc Link 19291593 Disease Relevance 0.43 Pain Relevance 0.27
r| > 0.80) with the electrophysiology indices according to the exposure time.
Gene_expression (levels) of MDA in sciatic nerve associated with sciatic nerve
12) Confidence 0.19 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18470611 Disease Relevance 0.16 Pain Relevance 0.54
RESULTS: The release of mast cell histamine and the generation of MDA are present only when mast cells were incubated with the drugs of abuse in the presence of oxidative enzymes.
Gene_expression (generation) of MDA in mast cell
13) Confidence 0.18 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9562337 Disease Relevance 0.15 Pain Relevance 0
Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not.
Gene_expression (production) of MDA associated with fluoxetine
14) Confidence 0.17 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18655806 Disease Relevance 0.28 Pain Relevance 0.44
The results showed that MDA levels increased significantly (P < 0.05) in nerve tissues, while GSH levels markedly decreased (P < 0.05) in a time-dependent manner.
Gene_expression (levels) of MDA in nerve
15) Confidence 0.16 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18470611 Disease Relevance 0.09 Pain Relevance 0.45
Neither single HBO(2) therapy nor five sequential daily treatments enhanced MDA production in lung tissue or serum.
Gene_expression (production) of MDA in lung
16) Confidence 0.16 Published 2004 Journal Shock Section Abstract Doc Link 15179139 Disease Relevance 0.38 Pain Relevance 0.06
Histamine release and MDA generation were abated by the free radical scavengers: reduced glutathione, 10(-4) M GSH and alpha-tocopherol, 10(-4) M and by the spin trapper 5.5-dimethyl-1-pyrroline-N-oxide, 10(-4) M DMPO.
Gene_expression (generation) of MDA
17) Confidence 0.15 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9562337 Disease Relevance 0.11 Pain Relevance 0
IAA and DEM produced a comparable, modest accumulation of MDA, yet IAA was much more cytotoxic.
Gene_expression (produced) of MDA
18) Confidence 0.13 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0.09 Pain Relevance 0.37
It is not known whether syntenin, synectin or CASK/LIN are enriched in nodes of Ranvier, but it seems likely that these or other PDZ-containing proteins could be involved in the organization of perinodal glial processes.
Gene_expression (enriched) of syntenin in nodes
19) Confidence 0.13 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC293377 Disease Relevance 0.07 Pain Relevance 0
MDA and NO levels were expressed as nmol/mg protein and ?
Gene_expression (expressed) of MDA
20) Confidence 0.12 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.45 Pain Relevance 0.03

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