INT35121

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.40
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 2
hepatocytes 2
lens 2
brainstem 2
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 37 99.88 Very High Very High Very High
fluoxetine 4 99.68 Very High Very High Very High
medulla 5 99.24 Very High Very High Very High
cINOD 2 98.76 Very High Very High Very High
Hippocampus 1 98.52 Very High Very High Very High
Serotonin 7 96.32 Very High Very High Very High
Dopamine 18 95.88 Very High Very High Very High
antidepressant 4 93.12 High High
diclofenac 1 88.92 High High
Paracetamol 83 86.36 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 9 99.10 Very High Very High Very High
Stress 28 98.88 Very High Very High Very High
INFLAMMATION 15 98.48 Very High Very High Very High
Heat Stroke 114 95.84 Very High Very High Very High
Heat Stress Disorders 6 94.40 High High
Pressure And Volume Under Development 6 92.88 High High
Depression 3 75.00 Quite High
Hypersensitivity 2 67.52 Quite High
Injury 20 67.20 Quite High
Peripheral Arterial Disease 1 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our results revealed that MDA also produced a loss of 5-HT fibers in brainstem that was as severe as that seen in any region of forebrain.
Negative_regulation (loss) of Gene_expression (produced) of MDA in brainstem associated with medulla
1) Confidence 0.43 Published 1993 Journal Brain Res. Section Abstract Doc Link 7690669 Disease Relevance 0 Pain Relevance 0.39
The three non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone, given 1 h before challenge, significantly inhibited LAC and plasma MDA levels at 4 h post challenge.
Negative_regulation (inhibited) of Gene_expression (levels) of plasma MDA in plasma associated with inflammation and cinod
2) Confidence 0.19 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 3117715 Disease Relevance 0.63 Pain Relevance 0.36
Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not.
Negative_regulation (inhibit) of Gene_expression (production) of MDA associated with fluoxetine
3) Confidence 0.10 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18655806 Disease Relevance 0.28 Pain Relevance 0.44
The combined agent (DXM+HES) reduces the levels of MDA, IL-1?
Negative_regulation (reduces) of Gene_expression (levels) of MDA associated with dexamethasone
4) Confidence 0.03 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 1.01 Pain Relevance 0.48
In addition to contributing to the maintenance of the membrane integrity of hepatocytes, as inferred from the lower plasma activities of ALT, AST and LDH, serving as markers of liver damage, these compounds were also able to markedly reduce the production of MDA, an indicator of LPO, and to return the intracellular levels of GSH to values that were equal to (HYTAU) or just below (NAC, TAU) the control value.
Negative_regulation (reduce) of Gene_expression (production) of MDA in hepatocytes associated with hepatotoxicity
5) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.17 Pain Relevance 0.17
We observed a significant decrease in MDA levels in the lens tissue with the administration of vitamin C in the PC monitor group, compared to the PC monitor alone group.
Negative_regulation (decrease) of Gene_expression (levels) of MDA in lens
6) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2787304 Disease Relevance 0.31 Pain Relevance 0

General Comments

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