INT35122

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Context Info
Confidence 0.51
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 22.01
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 3
diaphragm 1
stellate cells 1
lens 1
granulation 1
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 51 99.58 Very High Very High Very High
cINOD 15 98.76 Very High Very High Very High
Glutamate 20 98.52 Very High Very High Very High
anesthesia 24 98.36 Very High Very High Very High
aspirin 25 98.30 Very High Very High Very High
Dopamine 18 98.18 Very High Very High Very High
Paracetamol 12 94.80 High High
Calcium channel 6 93.52 High High
tolerance 3 92.80 High High
Calcitonin gene-related peptide 6 91.80 High High
Disease Link Frequency Relevance Heat
Stress 306 99.92 Very High Very High Very High
Injury 214 99.86 Very High Very High Very High
Diabetes Mellitus 17 99.84 Very High Very High Very High
Hypertension 194 99.76 Very High Very High Very High
Adhesions 25 99.72 Very High Very High Very High
Urological Neuroanatomy 4 99.52 Very High Very High Very High
Body Weight 68 99.42 Very High Very High Very High
Pancreatitis 19 98.88 Very High Very High Very High
Pressure Volume 2 Under Development 22 98.80 Very High Very High Very High
INFLAMMATION 171 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylsalicylic acid (ASA) at the same doses being injected at the lower one, induced the tendency toward the reduction of MDA level, while at the higher dose the rise of MDA content and CL intensity compared to PC have been observed.
Negative_regulation (reduction) of MDA associated with aspirin
1) Confidence 0.51 Published 1996 Journal Eksp Klin Farmakol Section Abstract Doc Link 8704633 Disease Relevance 0 Pain Relevance 0.25
The results demonstrate that in this experimental model, intraperitoneal administration of aminoguanidine decreases the incidence and extent of peritoneal adhesions and causes a decrease in MDA and NO and an increase in GSH values.
Negative_regulation (decrease) of MDA associated with adhesions
2) Confidence 0.35 Published 2006 Journal Cell Biochem. Funct. Section Abstract Doc Link 15991262 Disease Relevance 0.47 Pain Relevance 0.04
The extracts pretreatment resulted in a significant reduction in the free radical-mediated lipid peroxidation as indicated by a decrease in the MDA levels, at various dose levels (Figures 2 and 3).
Negative_regulation (decrease) of MDA
3) Confidence 0.26 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.46 Pain Relevance 0.20
The oxidative damage was measured in terms of enzymatic activity of MDA and MDA levels were found to decrease in their study.
Negative_regulation (decrease) of MDA
4) Confidence 0.19 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0.73 Pain Relevance 0.08
The three non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone, given 1 h before challenge, significantly inhibited LAC and plasma MDA levels at 4 h post challenge.
Negative_regulation (inhibited) of plasma MDA in plasma associated with inflammation and cinod
5) Confidence 0.19 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 3117715 Disease Relevance 0.63 Pain Relevance 0.36
The MDA level was also declined significantly in test groups.


Negative_regulation (declined) of MDA
6) Confidence 0.19 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1940022 Disease Relevance 0.57 Pain Relevance 0.18
The benefical effect of IP in rat sciatic nerve was manifested by a reduction in MDA tissue levels at 3th hour of reperfusion and ischemic fiber degeneration (IFD) at 7 th postischemic day of reperfusion, in the present study.
Negative_regulation (reduction) of MDA in sciatic nerve associated with sciatic nerve
7) Confidence 0.12 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1636295 Disease Relevance 0.53 Pain Relevance 0.14
This finding was concominant to the finding of decreased oxidative injury (i.e. decreased MDA levels in nerve tissue) seen in IP pretreated group.
Negative_regulation (decreased) of MDA in nerve associated with injury
8) Confidence 0.12 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1636295 Disease Relevance 0.63 Pain Relevance 0.10
IP reduces the severity of I/R injury in peripheral nerve as shown by reduced tissue MDA levels at 3 th hour of reperfusion and axonal vacoulization at 7 th postischemic day.



Negative_regulation (reduced) of MDA in peripheral nerve associated with injury
9) Confidence 0.09 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC1636295 Disease Relevance 0.53 Pain Relevance 0.23
The oxidative damage was measured in terms of enzymatic activity of MDA and MDA levels were found to decrease in their study.
Negative_regulation (decrease) of MDA
10) Confidence 0.08 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0.73 Pain Relevance 0.08
Pretreatment with i.p. melatonin (10 or 50 mg/kg), but not leptin, significantly reduced MDA + 4-HNE in the pancreas of CIP rats.
Negative_regulation (reduced) of MDA in pancreas associated with pancreatitis
11) Confidence 0.07 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11939719 Disease Relevance 0.70 Pain Relevance 0.31
CMN markedly reduced the elevated MDA levels, significantly increased the antioxidant enzyme activity and normalized the altered renal morphology in rats treated with APAP.
Negative_regulation (reduced) of MDA associated with paracetamol
12) Confidence 0.07 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 19345714 Disease Relevance 0.22 Pain Relevance 0.85
Although numerically decreased tissue MDA levels were detected in experimental groups of 2, 3, 4, and 5 compared to group 1, significant decreases were observed in only group 2 and group 5 (p < .05).
Negative_regulation (decreased) of MDA
13) Confidence 0.07 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.35 Pain Relevance 0
Table 3 demonstrates the effect of vitamin B6 deficiency on MDA levels.
Negative_regulation (deficiency) of MDA
14) Confidence 0.06 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.11 Pain Relevance 0
The mechanisms of the protective effects of taurine may be related to the decrease of MDA level and the increase of SOD and GPx activity.
Negative_regulation (decrease) of MDA
15) Confidence 0.05 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 0.77 Pain Relevance 0.07
Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities.
Negative_regulation (decreased) of MDA associated with urological neuroanatomy
16) Confidence 0.05 Published 2007 Journal J. Pineal Res. Section Abstract Doc Link 17614834 Disease Relevance 0.62 Pain Relevance 0.14
Quercetin-administrated rats showed significantly increased GSH level and decreased MDA level when compared with ethanol-treated rats, demonstrating the antioxidant effects of quercetin.
Negative_regulation (decreased) of MDA
17) Confidence 0.05 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.75 Pain Relevance 0
In the IR+Melatonin group, while MDA levels significantly decreased, SOD activities increased.
Negative_regulation (decreased) of MDA
18) Confidence 0.05 Published 2007 Journal Ren Fail Section Abstract Doc Link 17654314 Disease Relevance 0.93 Pain Relevance 0.42
There were evidences that the levels of SDH, SOD, GSH, AST, ALT were significantly increased by a taurine supplement in serum, and the level of MDA decreased [32-35].
Negative_regulation (decreased) of MDA
19) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.06 Pain Relevance 0
CONCLUSIONS: Sal-B treatment decreased MDA concentration in pancreatic tissue, attenuated morphological pancreatic damage, and prevented the activation of pancreatic stellate cells in experimental chronic pancreatitis.


Negative_regulation (decreased) of MDA in stellate cells
20) Confidence 0.05 Published 2009 Journal Pancreas Section Body Doc Link 18766118 Disease Relevance 0.06 Pain Relevance 0

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