INT351276

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2D6, CYP1A2) oxidoreductase activity (CYP2D6, CYP1A2) endoplasmic reticulum (CYP2D6, CYP1A2)
mitochondrion (CYP2D6) enzyme binding (CYP1A2)
CYP2D6 (Homo sapiens)
CYP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 84 99.80 Very High Very High Very High
Central nervous system 5 65.84 Quite High
fluoxetine 1 63.84 Quite High
Fibrositis 147 50.00 Quite Low
Dopamine 3 35.52 Quite Low
tricyclic antidepressant 7 33.12 Quite Low
Neurotransmitter 5 23.12 Low Low
5HT 2 22.72 Low Low
sNRI 12 18.56 Low Low
monoamine 2 12.56 Low Low
Disease Link Frequency Relevance Heat
Fibromyalgia 147 50.00 Quite Low
Pain 81 5.00 Very Low Very Low Very Low
Depression 34 5.00 Very Low Very Low Very Low
Fatigue 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 15 5.00 Very Low Very Low Very Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism, it is not surprising that drugs that inhibit these molecules have a profound effect on duloxetine metabolism and concentration.
CYP2D6 Regulation (responsible) of CYP1A2 associated with duloxetine
1) Confidence 0.12 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 0 Pain Relevance 0.63

General Comments

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