INT351284

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AP1M2) protein targeting (AP1M2) Golgi apparatus (AP1M2)
Anatomy Link Frequency
respiratory 2
AP1M2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Physical dependence 2 99.96 Very High Very High Very High
analgesia 106 99.48 Very High Very High Very High
depression 15 99.32 Very High Very High Very High
Morphine 27 92.24 High High
Codeine 18 91.44 High High
rapifen 1 87.76 High High
opioid receptor 6 87.68 High High
antagonist 6 85.68 High High
methadone 1 85.60 High High
agonist 15 85.20 High High
Disease Link Frequency Relevance Heat
Drug Dependence 2 99.96 Very High Very High Very High
Respiratory Failure 14 99.80 Very High Very High Very High
Heart Rate Under Development 5 98.84 Very High Very High Very High
Gastric Motility Disorder 1 97.32 Very High Very High Very High
Pain 99 78.32 Quite High
Muscle Hypertonia 1 53.52 Quite High
Mydriatic 1 50.40 Quite High
Post-operative Nausea 5 31.76 Quite Low
Exanthema 1 13.40 Low Low
Pruritus 5 12.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mu receptors are present as two types: mu1, when activated produce supraspinal analgesia and physical dependence; mu 2 receptors are responsible for respiratory depression, bradycardia, physical dependence, and gastrointestinal dysmotility.
Regulation (responsible) of Localization (receptors) of mu 2 in respiratory associated with heart rate under development, depression, physical dependence, respiratory failure, gastric motility disorder and analgesia
1) Confidence 0.04 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.85 Pain Relevance 1.90

General Comments

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