INT3513

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Context Info
Confidence 0.38
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.43
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Igha (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 5 95.20 Very High Very High Very High
Inflammation 14 75.00 Quite High
Pain 56 55.12 Quite High
psoriasis 20 5.00 Very Low Very Low Very Low
palliative 15 5.00 Very Low Very Low Very Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 20 99.76 Very High Very High Very High
Seronegative Spondarthritis 10 99.66 Very High Very High Very High
Syndrome 15 99.08 Very High Very High Very High
Colitis 18 99.04 Very High Very High Very High
Immunodeficiency 80 98.98 Very High Very High Very High
Membranous Glomerulonephritis 1 98.92 Very High Very High Very High
Peripheral Arterial Disease 255 98.64 Very High Very High Very High
Stress 40 98.08 Very High Very High Very High
Iga Nephropathy 1 96.44 Very High Very High Very High
Disease 143 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgA deposition with other immunoglobulins was seen in over 50% of cases, with an IgA IgG-Beta1C-globulin combination being the common lesion.
Negative_regulation (deposition) of IgA
1) Confidence 0.38 Published 1976 Journal Clin. Nephrol. Section Abstract Doc Link 780026 Disease Relevance 1.00 Pain Relevance 0.06
RESULTS: IgM and IgA were decreased in patients with untreated AIP.
Negative_regulation (decreased) of IgA
2) Confidence 0.05 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19626266 Disease Relevance 0.17 Pain Relevance 0
One patient with 'unclassified' seronegative spondarthritis showed complete absence of IgA and IgM in his serum.
Negative_regulation (absence) of IgA associated with seronegative spondarthritis
3) Confidence 0.05 Published 1983 Journal Br. J. Rheumatol. Section Abstract Doc Link 6871581 Disease Relevance 1.27 Pain Relevance 0.41
Persons with selective IgA deficiency had significantly higher QLI scores than those with other antibody deficiencies.
Negative_regulation (deficiency) of IgA
4) Confidence 0.02 Published 2005 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC1177979 Disease Relevance 0.39 Pain Relevance 0
Patients with symptomatic selective IgA deficiency are usually healthier than other PAD patients [2].
Negative_regulation (deficiency) of IgA associated with peripheral arterial disease
5) Confidence 0.02 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 0.40 Pain Relevance 0.05
Primary antibody deficiencies (PAD) constitute the largest subgroup and include: Common Variable Immunodeficiency, X-linked (Brutons) Agammaglobulinemia, Selective IgA deficiency, IgG subclass deficiency, and Hyper IgM syndrome [1].
Negative_regulation (deficiency) of IgA associated with syndrome, agammaglobulinemia, peripheral arterial disease and immunodeficiency
6) Confidence 0.02 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 1.20 Pain Relevance 0
Distribution of the specific PAD diagnoses was: Common Variable Immunodeficiency (n = 43), X-linked Agammaglobulinemi (n = 3), Selective IgA deficiency (n = 8) and Hyper IgM syndrome (n = 1).
Negative_regulation (deficiency) of IgA associated with syndrome, peripheral arterial disease and immunodeficiency
7) Confidence 0.02 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 1.17 Pain Relevance 0
The cohort included 50 men and 41 women, aged 20–82 years, with various PAD diagnoses: Common variable immunodeficiency (n = 66), X-linked Agammaglobulinemia (n = 8), Selective IgA deficiency (n = 16) and Hyper IgM syndrome (n = 1).
Negative_regulation (deficiency) of IgA associated with syndrome, agammaglobulinemia, peripheral arterial disease and immunodeficiency
8) Confidence 0.02 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 1.12 Pain Relevance 0
The serum immunoglobulin (Ig)E level decreased in IO treatment groups (C, D) compared to no IO treatment groups (A and B) although there was no significant difference between the IO treatment groups.
Negative_regulation (l decreas) of serum immunoglobulin
9) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2840610 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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