INT351311

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) transferase activity, transferring glycosyl groups (Has1) nucleus (MMP3)
Anatomy Link Frequency
cartilage 2
Has1 (Mus musculus)
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 100.00 Very High Very High Very High
cytokine 2 99.08 Very High Very High Very High
Inflammatory mediators 2 98.48 Very High Very High Very High
Osteoarthritis 28 96.68 Very High Very High Very High
Pain 50 96.44 Very High Very High Very High
Neuropeptide 1 90.76 High High
Inflammation 5 79.08 Quite High
corticosteroid 7 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 98.08 Very High Very High Very High
Osteoarthritis 29 96.68 Very High Very High Very High
Pain 49 96.44 Very High Very High Very High
Shock 1 84.12 Quite High
Apoptosis 1 66.44 Quite High
Disease 5 61.36 Quite High
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HA has been shown to stimulate endogenous HA synthesis by synovial sites through CD 44 receptor binding.12,20 Exogenous HA downregulates matrix metalloproteinase-3 expression and inhibit metalloproteinase synthesis which results in decreased cartilage destruction.
has Regulation (stimulate) of Gene_expression (expression) of matrix metalloproteinase-3 in cartilage associated with metalloproteinase
1) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004653 Disease Relevance 1.15 Pain Relevance 0.95

General Comments

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