INT351349

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.00 Pain Relevance 2.82

plasma membrane (Prkcg, Lpar1) cytoplasm (Prkcg, Lpar1) cytosol (Prkcg) nucleus (Prkcg) intracellular (Prkcg) signal transducer activity (Lpar1)

Prkcg (Rattus norvegicus) Lpar1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Kinase C 74 100.00 Glutamate 2 93.84 dorsal root ganglion 106 92.32 Inflammation 10 91.04 Cancer pain 40 75.76 Neuropathic pain 20 74.48 tetrodotoxin 4 70.48 bradykinin 4 68.16 substance P 6 65.52 nociceptor 12 63.52

Disease Link Frequency Relevance Heat Ganglion Cysts 108 92.32 INFLAMMATION 14 91.04 Nociception 10 79.04 Bone Cancer 86 76.16 Neuropathic Pain 32 74.48 Pain 22 47.12 Targeted Disruption 2 31.76 Hyperalgesia 10 21.76 Cancer 66 5.00 Carcinoma 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, the interaction of LPA1 and TRPV1 is mediated by PKC, particularly by PKC?

PKC Positive_regulation (mediated) of LPA1 Binding (interaction) of associated with kinase c

1) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.03 Pain Relevance 1.43

Taken together, the interaction of LPA1 and TRPV1 is mediated by PKC, particularly by PKC?

PKC Positive_regulation (mediated) of LPA1 Binding (interaction) of associated with kinase c

2) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.97 Pain Relevance 1.39

General Comments

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