INT35135

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lipe) mitochondrion (Lipe) extracellular space (Lipe)
lipid particle (Lipe) plasma membrane (Lipe) nucleus (Lipe)
Anatomy Link Frequency
adipose tissue 2
Lipe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 99.72 Very High Very High Very High
cytokine 42 95.68 Very High Very High Very High
addiction 1 88.00 High High
Inflammation 38 75.48 Quite High
Inflammatory response 14 12.44 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 81 99.92 Very High Very High Very High
Syndrome 10 96.80 Very High Very High Very High
INFLAMMATION 52 75.48 Quite High
Acute-phase Reaction 2 73.16 Quite High
Injury 2 71.60 Quite High
Disorder Of Lipid Metabolism 6 36.96 Quite Low
Stress 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet.
Positive_regulation (elevate) of HSL in adipose tissue associated with qutenza and obesity
1) Confidence 0.45 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3118870 Disease Relevance 0.10 Pain Relevance 0.34
HSL was increased in the trained, overtrained and recovered groups (all groups, p < 0.05), when compared with the control group.
Positive_regulation (increased) of HSL
2) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.25 Pain Relevance 0.04
In addition, we observed increased HSL in the trained, overtrained and recovered groups and decreased perilipin protein expression in the adipose tissue of the trained and recovered groups.
Positive_regulation (increased) of HSL in adipose tissue associated with obesity
3) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.90 Pain Relevance 0.21

General Comments

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