INT351352

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.86
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv1, Lpar1) cytosol (Trpv1) cytoplasm (Lpar1)
signal transducer activity (Lpar1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 3
DRG 2
Trpv1 (Rattus norvegicus)
Lpar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 318 99.84 Very High Very High Very High
Kinase C 222 99.36 Very High Very High Very High
Lasting pain 12 98.16 Very High Very High Very High
Cancer pain 120 96.88 Very High Very High Very High
qutenza 144 95.68 Very High Very High Very High
Glutamate 6 93.84 High High
Inflammation 30 91.04 High High
Root ganglion neuron 6 89.84 High High
Neuropathic pain 60 71.28 Quite High
bradykinin 12 68.16 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 324 99.36 Very High Very High Very High
Pain 66 98.16 Very High Very High Very High
Bone Cancer 258 97.08 Very High Very High Very High
Injury 12 93.48 High High
INFLAMMATION 42 91.04 High High
Cancer 198 88.00 High High
Carcinoma 18 87.36 High High
Nociception 30 75.84 Quite High
Neuropathic Pain 96 71.28 Quite High
Hyperalgesia 30 35.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the possible cross-talk between TRPV1 and LPA1, double immunolabeling of the TRPV1 and LPA1 receptor (EDG-2) was detected in the DRG neurons.
TRPV1 Binding (immunolabeling) of LPA1 receptor in neurons associated with dorsal root ganglion
1) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.90 Pain Relevance 0.60
To investigate the possible cross-talk between TRPV1 and LPA1, double immunolabeling of the TRPV1 and LPA1 receptor (EDG-2) was detected in the DRG neurons.
TRPV1 Binding (immunolabeling) of EDG-2 in neurons associated with dorsal root ganglion
2) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.90 Pain Relevance 0.60
To investigate the possible cross-talk between TRPV1 and LPA1, double immunolabeling of the TRPV1 and LPA1 receptor (EDG-2) was detected in the DRG neurons.
TRPV1 Binding (immunolabeling) of LPA1 in neurons associated with dorsal root ganglion
3) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.89 Pain Relevance 0.59
In the present study we examined whether an interaction between LPA receptor LPA1 and TRPV1 in dorsal root ganglion (DRG) neurons contributes to the development of bone cancer pain.


TRPV1 Spec (whether) Binding (interaction) of LPA1 in DRG associated with ganglion cysts, dorsal root ganglion, cancer pain and bone cancer
4) Confidence 0.20 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3004845 Disease Relevance 1.10 Pain Relevance 0.74
Taken together, the interaction of LPA1 and TRPV1 is mediated by PKC, particularly by PKC?
TRPV1 Binding (interaction) of LPA1 associated with kinase c
5) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.96 Pain Relevance 1.35
In the present study we examined whether an interaction between LPA receptor LPA1 and TRPV1 in dorsal root ganglion (DRG) neurons contributes to the development of bone cancer pain.


TRPV1 Spec (whether) Binding (interaction) of LPA receptor in DRG associated with ganglion cysts, dorsal root ganglion, cancer pain and bone cancer
6) Confidence 0.17 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3004845 Disease Relevance 1.10 Pain Relevance 0.74

General Comments

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