INT351356

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.98 Pain Relevance 1.41

plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)

Lpar1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 53 99.84 Kinase C 37 92.32 nociceptor 6 90.00 Cancer pain 20 88.48 Pain 9 85.16 Inflammatory mediators 2 79.52 Thermal hyperalgesia 5 74.08 allodynia 5 73.08 antagonist 6 69.52 Neuropathic pain 10 67.40

Disease Link Frequency Relevance Heat Ganglion Cysts 54 99.84 Bone Cancer 43 99.76 Pain 11 85.16 Targeted Disruption 1 84.08 INFLAMMATION 7 79.52 Nociception 5 79.20 Hyperalgesia 5 74.08 Neuropathic Pain 16 73.08 Stress 1 21.28 Nervous System Injury 1 20.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The findings that co-localization of TRPV1 and LPA1 receptor EDG-2 and bone cancer induced an increase in LPA1 receptor expression in DRG [40] provide further support for these phenomena.

Positive_regulation (increase) of Gene_expression (expression) of LPA1 receptor associated with dorsal root ganglion and bone cancer

1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.98 Pain Relevance 1.41

General Comments

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