INT351364

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (LPA, Trpv1) cytosol (Trpv1) peptidase activity (LPA)
transport (LPA) small molecule metabolic process (LPA) extracellular region (LPA)
Anatomy Link Frequency
nociceptors 1
LPA (Homo sapiens)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 20 100.00 Very High Very High Very High
nociceptor 6 99.48 Very High Very High Very High
Kinase C 37 91.28 High High
dorsal root ganglion 53 90.20 High High
Neuropathic pain 10 72.24 Quite High
nav1.8 2 49.04 Quite Low
Pain 9 47.32 Quite Low
sodium channel 1 43.60 Quite Low
substance P 3 38.40 Quite Low
tetrodotoxin 2 35.96 Quite Low
Disease Link Frequency Relevance Heat
Bone Cancer 43 100.00 Very High Very High Very High
Cancer 33 100.00 Very High Very High Very High
Ganglion Cysts 54 90.20 High High
Cancer Pain 3 89.60 High High
Neuropathic Pain 16 72.24 Quite High
Pain 11 47.32 Quite Low
Carcinoma 3 41.36 Quite Low
Nociception 5 31.64 Quite Low
INFLAMMATION 7 9.00 Low Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Released by cancer cells and blood platelets, LPA not only promotes cancer cell proliferation but also contributes to the induction of bone cancer pain by enhancing TRPV1 activity in nociceptors.
LPA Positive_regulation (enhancing) of TRPV1 in nociceptors associated with cancer pain, cancer, nociceptor and bone cancer
1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.15 Pain Relevance 0.78

General Comments

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