INT351376

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.54
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
sensory nerve 1
Mir470 (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cancer pain 23 98.28 Very High Very High Very High
Pain 30 95.96 Very High Very High Very High
Lasting pain 3 93.96 High High
Nerve growth factor 25 89.04 High High
Inflammation 6 5.00 Very Low Very Low Very Low
Analgesic 5 5.00 Very Low Very Low Very Low
c fibre 4 5.00 Very Low Very Low Very Low
nociceptor 4 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 13 98.18 Very High Very High Very High
Cancer 55 96.56 Very High Very High Very High
Pain 31 95.96 Very High Very High Very High
Cancer Pain 11 86.04 High High
Neuroma 25 75.00 Quite High
Sarcoma 8 75.00 Quite High
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report, we use a mouse model of bone cancer pain and examine whether oral administration of a selective small molecule Trk inhibitor (ARRY-470, which blocks TrkA, TrkB and TrkC kinase activity at low nm concentrations) has a significant effect on cancer-induced pain behaviors, tumor-induced remodeling of sensory nerve fibers, tumor growth and tumor-induced bone remodeling.
ARRY-470 Negative_regulation (blocks) of TrkA in sensory nerve associated with pain, cancer pain, cancer and bone cancer
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3004846 Disease Relevance 1.54 Pain Relevance 0.70

General Comments

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