INT351379

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, Ngf) extracellular space (Ngf, Ngf) extracellular region (Ngf, Ngf)
cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
Anatomy Link Frequency
neurons 2
Ngf (Mus musculus)
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 25 100.00 Very High Very High Very High
nociceptor 4 99.32 Very High Very High Very High
unmyelinated 2 98.20 Very High Very High Very High
Pain 30 89.68 High High
Cancer pain 23 83.88 Quite High
Neurotransmitter 1 81.44 Quite High
Inflammation 6 60.12 Quite High
c fibre 4 44.56 Quite Low
Analgesic 5 6.64 Low Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 31 89.68 High High
Bone Cancer 13 83.68 Quite High
INFLAMMATION 6 60.12 Quite High
Injury 5 59.04 Quite High
Hyperalgesia 3 51.76 Quite High
Neuroma 25 50.00 Quite Low
Sarcoma 8 50.00 Quite Low
Cancer 55 49.92 Quite Low
Hypercalcemia 1 34.00 Quite Low
Bone Fracture 1 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20].
NGF Positive_regulation (activate) of NGF Binding (binding) of TrkA in neurons associated with nerve growth factor and nociceptor
1) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.63 Pain Relevance 1.21

General Comments

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