INT351386

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 54 50.80 Quite High
Inflammation 4 43.72 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 52 95.36 Very High Very High Very High
Neurodegenerative Disease 84 94.36 High High
Alzheimer's Dementia 22 92.32 High High
Targeted Disruption 192 90.24 High High
Amyloid Plaque 10 75.16 Quite High
INFLAMMATION 4 43.72 Quite Low
Gliosis 4 39.00 Quite Low
Disease 40 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, triggers a cascade of protective events ranging from the activation of the canonical Wnt pathway to a reduction of APP phosphorylation and thereby a lesser accumulation of A?
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of APP
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.34 Pain Relevance 0.03
load was associated with a significant reduction in APP phosphorylation and in 7-month-old TgCRND8 mice with a decrease in PHF-1 tau hyperphosphorylation.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of APP
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.48 Pain Relevance 0

General Comments

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