INT35141

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.64
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
plasma 1
parathyroid 1
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 47 100.00 Very High Very High Very High
bradykinin 21 99.16 Very High Very High Very High
Inflammation 13 98.20 Very High Very High Very High
Inflammatory response 5 95.92 Very High Very High Very High
withdrawal 2 82.64 Quite High
Pain 7 72.64 Quite High
anesthesia 2 25.00 Low Low
Spinal cord 1 23.60 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 31 99.46 Very High Very High Very High
Neuroblastoma 1 99.28 Very High Very High Very High
INFLAMMATION 18 98.20 Very High Very High Very High
Hereditary Angioedema 64 98.04 Very High Very High Very High
Hypercalcemia 7 95.36 Very High Very High Very High
Increased Venous Pressure Under Development 5 91.36 High High
Breast Cancer 60 80.80 Quite High
Targeted Disruption 5 73.76 Quite High
Pain 4 72.64 Quite High
Disease 7 59.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we review the evidences indicating a role of the plasminogen activation system in the regulation of all the phases of the inflammation process.
Regulation (role) of plasminogen associated with inflammation
1) Confidence 0.44 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.60 Pain Relevance 0.29
For example in vitro addition of plasmin, a serine protease, accelerates the migration of neuroblastoma cells through a matrigel base by a factor of five [7].
Regulation (accelerates) of plasmin associated with neuroblastoma
2) Confidence 0.44 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.17 Pain Relevance 0
However, the strong linkage of bradykinin and angioedema attacks does not preclude involvement of other plasma cascade products, such as plasmin and thrombin, in the initiation and duration of HAE attacks.
Regulation (involvement) of plasmin in plasma associated with pressure and volume under development, hereditary angioedema and bradykinin
3) Confidence 0.44 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 1.25 Pain Relevance 0.24
In contrast, cPUK did not change the plasminogen and fibrinogen levels and induced a substantially smaller decline in alpha 2-antiplasmin than cLUK.
Neg (not) Regulation (change) of plasminogen
4) Confidence 0.30 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
Regulation of the PA/plasmin system is achieved mainly via plasminogen activator inhibitor (PAI) type-1 and type-2 and by agents that stimulate bone resorption, e.g. parathyroid hormone (PTH) and interleukin (IL)-1 [8].
Regulation (Regulation) of plasmin in parathyroid associated with hypercalcemia
5) Confidence 0.26 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.35 Pain Relevance 0.18
MSE, striking up-regulation of metalloproteinases (MMPs and ADAMs), serine proteases [the plasminogen activators, uPA (PLAU) and tPA (PLAT)], and their inhibitors, was observed [14].
Regulation (regulation) of plasminogen associated with metalloproteinase
6) Confidence 0.07 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.26 Pain Relevance 0.14

General Comments

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