INT35143

Context Info Confidence 0.54 First Reported 1987 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 28 Total Number 29 Disease Relevance 18.59 Pain Relevance 3.14

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)

Anatomy Link Frequency plasma 5 platelet 3 blood 1 liver 1 immune cell 1 ANGPTL5 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 48 98.88 bradykinin 2 98.88 Inflammation 76 98.16 Inflammatory response 55 97.24 antagonist 35 96.00 Pain 27 95.00 Angina 12 94.16 beta blocker 1 89.88 Analgesic 7 89.56 aspirin 9 88.72

Disease Link Frequency Relevance Heat Coagulation Disorder 51 100.00 Jaundice 3 99.88 Afibrinogenemia 6 99.62 Acidosis 10 99.60 Encephalopathy 4 99.24 Cv General 3 Under Development 20 98.88 Hepatotoxicity 9 98.72 Shock 134 98.40 Adhesions 9 98.36 Disorder Of Lipid Metabolism 189 98.20

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Mutation

Event

Anatomy

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Speculation

Pain term

Disease term

Fibrinogen levels decreased to 65 +/- 21% of baseline at 90 minutes of rt-PA infusion.

Negative_regulation (decreased) of Fibrinogen

1) Confidence 0.54 Published 1988 Journal Circulation Section Abstract Doc Link 3136953 Disease Relevance 0.70 Pain Relevance 0.09

Fig. 4 shows that there was a sustained reduction of approximately 14% in plasma fibrinogen attributable to active treatment.

Negative_regulation (reduction) of fibrinogen in plasma

2) Confidence 0.46 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.23 Pain Relevance 0

Ancrod, snake venom from the Malayan pit viper, was used to lower plasma fibrinogen levels, which allowed successful cardiac catheterization and coronary artery bypass grafting.

Negative_regulation (lower) of fibrinogen in plasma

3) Confidence 0.41 Published 1996 Journal Heart Lung Section Abstract Doc Link 8950124 Disease Relevance 0.92 Pain Relevance 0.18

Contrary to the previous reports on Binswanger-type encephalopathy, both of these patients demonstrated decreased levels of fibrinogen as well as those of factor V, together with negative antiphospholipid antibody.

Negative_regulation (decreased) of fibrinogen associated with encephalopathy

4) Confidence 0.41 Published 1996 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8752690 Disease Relevance 1.16 Pain Relevance 0.17

Afibrinogenaemia is a quantitative deficiency of fibrinogen that is associated with an increased bleeding tendency.

Negative_regulation (deficiency) of fibrinogen associated with afibrinogenemia and cva

5) Confidence 0.39 Published 2008 Journal Singapore Med J Section Abstract Doc Link 18418510 Disease Relevance 0.81 Pain Relevance 0.13

Although bezafibrate lowers fibrinogen, it has no effect on CRP; this suggests that the reduction in fibrinogen is due to an effect on its metabolism rather than suppression of an inflammatory response.

Negative_regulation (reduction) of fibrinogen associated with inflammatory response

6) Confidence 0.34 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Abstract Doc Link PMC57751 Disease Relevance 0.39 Pain Relevance 0.05

There has been a sustained reduction in plasma fibrinogen that would also be expected to be beneficial.

Negative_regulation (reduction) of fibrinogen in plasma

7) Confidence 0.34 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.58 Pain Relevance 0.04

The full reduction in fibrinogen levels in LEADER appeared to occur only after approximately 6 months on treatment (Fig. 4).

Negative_regulation (reduction) of fibrinogen

8) Confidence 0.34 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.51 Pain Relevance 0

Based on these results, we conclude that reducing fibrinogen:surface interactions should enhance biocompatibility and that administration of histamine receptor antagonists prior to, and shortly after, medical device implantation should improve the functionality and longevity of medical implants.

Negative_regulation (reducing) of fibrinogen associated with aging and antagonist

9) Confidence 0.12 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1929055 Disease Relevance 0.33 Pain Relevance 0.24

The results support the general conclusion that biocompatibility might be improved by the design of surfaces which reduce fibrinogen adsorption and denaturation.

Negative_regulation (reduce) of fibrinogen

10) Confidence 0.12 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.69 Pain Relevance 0.31

Fibrinolytic activity of cLUK was accompanied by a decrease in alpha 2-antiplasmin, plasminogen and fibrinogen.

Negative_regulation (decrease) of fibrinogen

11) Confidence 0.11 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0

Direct acidification of the blood can reduce circulating fibrinogen levels by increasing breakdown without increasing production [40].

Negative_regulation (reduce) of fibrinogen in blood

12) Confidence 0.10 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC3006355 Disease Relevance 1.03 Pain Relevance 0.03

In addition, the lack of a direct association of oxygen consumption with fibrinogen and the mild overall acidosis indicates that the reduction in fibrinogen we observed should not be attributed entirely to the effects of tissue hypoperfusion or acidosis.

Negative_regulation (reduction) of fibrinogen associated with acidosis

13) Confidence 0.10 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC3006355 Disease Relevance 0.93 Pain Relevance 0

The coagulation profile showed a fibrinogen level of 879 mg/dl and antithrombin III value of 9.5%.

Negative_regulation (level) of fibrinogen

14) Confidence 0.07 Published 2000 Journal Surg. Today Section Abstract Doc Link 10930236 Disease Relevance 0.92 Pain Relevance 0.20

Immunofluorescence studies revealed intensive deposition of IgG, IgA, C3, C1q, Fibrinogen, and kappa light chain with granular pattern in the capillary and mesangial area.

Negative_regulation (deposition) of Fibrinogen in capillary

15) Confidence 0.07 Published 2009 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 19367362 Disease Relevance 0.77 Pain Relevance 0.27

The patient's purified fibrinogen was normal, but his serum contained an IgG that inhibited the clotting of normal plasma and purified fibrinogen in the presence of thrombin.

Negative_regulation (inhibited) of fibrinogen in plasma associated with coagulation disorder

16) Confidence 0.06 Published 1987 Journal Am. J. Hematol. Section Abstract Doc Link 3578266 Disease Relevance 0.45 Pain Relevance 0.08

The CFA effectively removed 93% of CG, without significant removal of IgG, IgM, IgA, albumin, and fibrinogen.

Negative_regulation (removal) of fibrinogen

17) Confidence 0.06 Published 1999 Journal ASAIO J. Section Abstract Doc Link 10360729 Disease Relevance 1.28 Pain Relevance 0.07

Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha 2-antiplasmin, decreased alpha 1-antitrypsin, and decreased alpha 2-macroglobulin.

Negative_regulation (decreased) of fibrinogen in platelet associated with adhesions

18) Confidence 0.04 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.93 Pain Relevance 0.07

Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.

Negative_regulation (decreased) of fibrinogen in plasma

19) Confidence 0.04 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0

However, event rate was not significantly reduced (p = 0.26) despite reductions of 5% in LDL-C, 16% in triglyceride, and 10% in fibrinogen levels, together with an increase of 14% in HDL-C levels compared with placebo.

Negative_regulation (reductions) of fibrinogen associated with disorder of lipid metabolism

20) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.81 Pain Relevance 0

General Comments

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