INT351444

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Gria2) endoplasmic reticulum (Gria2) enzyme binding (Grin1)
protein complex (Gria2) cytoplasm (Grin1)
Anatomy Link Frequency
synapses 1
Grin1 (Rattus norvegicus)
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 204 100.00 Very High Very High Very High
depression 178 100.00 Very High Very High Very High
Dopamine 88 100.00 Very High Very High Very High
Endocannabinoid 4 98.88 Very High Very High Very High
Cannabinoid 108 92.96 High High
Hippocampus 4 88.36 High High
withdrawal 2 81.16 Quite High
long-term potentiation 48 80.96 Quite High
cocaine 22 80.72 Quite High
Glutamate 10 71.68 Quite High
Disease Link Frequency Relevance Heat
Depression 178 100.00 Very High Very High Very High
Recurrence 8 78.56 Quite High
Cannabis Dependence 8 68.16 Quite High
Drug Dependence 12 56.36 Quite High
Mental Disorders 2 45.68 Quite Low
Stress 2 40.72 Quite Low
Anxiety Disorder 8 32.64 Quite Low
Li-fraumeni Syndrome 32 22.76 Low Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we provide the first evidence, to our knowledge, suggesting that NMDAR-dependent LTD at VTA local Glu-DA synapses requires GluR2 endocytosis.
NMDAR Positive_regulation (requires) of GluR2 in synapses associated with ventral tegmentum and depression
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.74 Pain Relevance 1.55
While mGluR-dependent LTD in VTA dopamine circuitry requires the exchange of GluR2-lacking AMPARs for those containing this subunit [16], [35], we demonstrate here that NMDAR-dependent LTD in VTA dopamine circuitry requires GluR2 endocytosis.
NMDAR Positive_regulation (requires) of GluR2 associated with ventral tegmentum, dopamine and depression
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.76 Pain Relevance 1.09

General Comments

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