INT35146

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 17.63
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
plasma 3
myocyte 1
blood 1
brain 1
platelet 1
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 31 98.36 Very High Very High Very High
Central nervous system 13 94.88 High High
metalloproteinase 162 93.72 High High
opioid receptor 2 92.96 High High
MU agonist 1 90.96 High High
antagonist 15 89.36 High High
cytokine 55 88.48 High High
Spinal cord 3 80.80 Quite High
ischemia 12 80.60 Quite High
cva 18 79.96 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 118 99.84 Very High Very High Very High
Cirrhosis 51 99.70 Very High Very High Very High
Hyperglycemia 26 99.40 Very High Very High Very High
Disease 239 99.32 Very High Very High Very High
Myocardial Infarction 118 98.76 Very High Very High Very High
Hypothermia 14 98.68 Very High Very High Very High
Death 74 98.60 Very High Very High Very High
Pressure Volume 2 Under Development 43 98.08 Very High Very High Very High
Hypoxia 1 97.36 Very High Very High Very High
Stress 147 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, I prepared a specific plasmin inhibitor (YO-2) and a plasma kallikrein inhibitor (PKSI-527).
Negative_regulation (inhibitor) of plasmin in plasma
1) Confidence 0.57 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19797870 Disease Relevance 0 Pain Relevance 0.39
Inhibition of the serine protease plasmin appears to have therapeutic advantage in myocardial infarct patients.


Negative_regulation (Inhibition) of plasmin associated with myocardial infarction
2) Confidence 0.57 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.21 Pain Relevance 0.08
Representative, the serine protease inhibitor camostat mesilate was recently found to suppress HSC activation by inhibiting hepatic plasmin activity and thereby preventing hepatic fibrosis [31].
Negative_regulation (inhibiting) of plasmin associated with fibrosis and cirrhosis
3) Confidence 0.57 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC270053 Disease Relevance 0.67 Pain Relevance 0.13
Inhibition of plasmin by doxycycline may reduce myocyte death and contribute to cardioprotection.
Negative_regulation (Inhibition) of plasmin in myocyte associated with death
4) Confidence 0.57 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.25 Pain Relevance 0.12
In a randomized, prospective trial of patients undergoing CPB surgery, we demonstrated that the synthetic antifibrinolytic drug tranexamic acid effectively suppresses fibrinolysis by inhibiting t-PA and plasmin activity with clear reduction of perioperative blood loss.
Negative_regulation (inhibiting) of plasmin in blood associated with pressure volume 2 under development
5) Confidence 0.57 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738071 Disease Relevance 0.32 Pain Relevance 0.06
In the fibrinolytic pathway, C1-inhibitor participates in the inactivation of plasmin and tissue plasminogen activator (tPA).
Negative_regulation (inactivation) of plasmin
6) Confidence 0.42 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.39 Pain Relevance 0.07
Doxycycline inhibits the serine protease plasmin while treatment with a broad spectrum MMP inhibitor had no effect.
Negative_regulation (inhibits) of plasmin
7) Confidence 0.42 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.31 Pain Relevance 0.10
TXA and EACA therefore have a dual mechanism of anticoagulation: decreased fibrinolysis and decreased platelet aggregation due to the inactivation of plasmin.
Negative_regulation (inactivation) of plasmin in platelet
8) Confidence 0.42 Published 2010 Journal BMC Surg Section Body Doc Link PMC2858129 Disease Relevance 1.15 Pain Relevance 0.10
Interestingly, plasmin levels are reduced in the brain of AD patients [103], although plasmin is a proteinase that cleaves proNGF and proBDNF in vitro, but its activity in vivo is still uncertain.
Negative_regulation (reduced) of plasmin in brain associated with disease
9) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.41 Pain Relevance 0.08
Of these, plasminogen activator inhibitor-1 (PAI-1) is considered to be the main inhibitor of t-PA in the vascular compartments, Additionally, ?
Negative_regulation (inhibitor-1) of plasmin
10) Confidence 0.41 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.60 Pain Relevance 0.10
The subsequent addition of aprotinin, a plasmin inhibitor, decreases the migratory population to the same degree [8,9].
Negative_regulation (inhibitor) of plasmin
11) Confidence 0.41 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.18 Pain Relevance 0
Lipoprotein (a) has a structure similar to that of plaminogen and may reduce plasmin generation and impair fibrinolysis, inducing a prothrombotic state.
Negative_regulation (reduce) of plasmin
12) Confidence 0.41 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.20 Pain Relevance 0.14
PAI-1 plays an important role in the process of peripheral tissue remodeling and fibrinolysis through inhibition of plasmin-dependent ECM degradation [67].
Negative_regulation (inhibition) of plasmin
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.52 Pain Relevance 0.09
Interestingly, anticoagulative factors, namely protein C and plasmin-antiplasmin complexes were also significantly lower during the hyperthyroid period.
Negative_regulation (lower) of plasmin
14) Confidence 0.41 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2831875 Disease Relevance 1.12 Pain Relevance 0
Interestingly, anticoagulative factors, namely protein C and plasmin-antiplasmin complexes were also significantly lower during the hyperthyroid period.
Negative_regulation (lower) of plasmin
15) Confidence 0.41 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2831875 Disease Relevance 1.17 Pain Relevance 0
Fibrinolytic activity of cLUK was accompanied by a decrease in alpha 2-antiplasmin, plasminogen and fibrinogen.
Negative_regulation (decrease) of plasminogen
16) Confidence 0.39 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
To investigate the possible role of the PAS in collagen breakdown by breast cancer cells, plasminogen was depleted from FCS by lysine-Sepharose chromatography [14].
Negative_regulation (depleted) of plasminogen associated with breast cancer
17) Confidence 0.33 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.71 Pain Relevance 0.03
Interestingly, the depletion of plasminogen from serum also completely blocked breast cancer cell mediated collagen dissolution, implicating the PAS in breast cancer-mediated collagen degradation (Fig. 1).
Negative_regulation (depletion) of plasminogen associated with breast cancer
18) Confidence 0.33 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.72 Pain Relevance 0.03
It was found that immediately after rHuIFN-gamma treatment, tissue plasminogen activator activity and antigen levels were not significantly decreased in volunteers.
Neg (not) Negative_regulation (decreased) of plasminogen
19) Confidence 0.28 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.50 Pain Relevance 0.07
These data suggest that rHuIFN-gamma may stimulate the expression of another plasminogen activator inhibitor.
Negative_regulation (inhibitor.) of plasminogen
20) Confidence 0.23 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.31 Pain Relevance 0.06

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