INT351491

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 8 47.44 Quite Low
imagery 10 15.44 Low Low
Pain 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 830 100.00 Very High Very High Very High
Toxicity 15 93.92 High High
Apoptosis 13 50.24 Quite High
Disorder Of Lipid Metabolism 3 44.48 Quite Low
Cognitive Disorder 21 36.84 Quite Low
Attention Deficit Hyperactivity Disorder 6 32.48 Quite Low
Dementia 12 31.64 Quite Low
Disease 61 20.48 Low Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Neuropathic Pain 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, tocotrienol, a member of the vitamin E family that was reported to induce IKAP expression in FD cells [36], [37], [38], did not affect IKAP mRNA expression in our system (Figure 7B); this observation is similar to that of another publication [39].
Neg (not) Regulation (affect) of Gene_expression (expression) of IKAP mRNA associated with familial dysautonomia
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.78 Pain Relevance 0
Using the hOE-MSCs model, we were also able to modulate the expression of IKBKAP WT and MU transcripts, by exposing the cells to different culture conditions to simulate variations in alternative splicing occurring during development and differentiation. hOE-MSCs form free floating spheres in approximately 7 days, when cultured with EGF and bFGF in serum-free medium.
Regulation (modulate) of Gene_expression (expression) of IKBKAP
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.40 Pain Relevance 0
Since MU transcripts contain a premature stop codon that may activate the nonsense-mediated mRNA decay (NMD) pathway, we wanted to confirm whether this pathway is responsible for the lower IKBKAP transcripts expression in FD cells.
Spec (whether) Regulation (responsible) of Gene_expression (expression) of IKBKAP associated with familial dysautonomia
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.59 Pain Relevance 0
We also demonstrated that long time culture conditions and trypsin-EDTA mediated cell passages did not affect the IKBKAP gene expression pattern.
Neg (not) Regulation (affect) of Gene_expression (expression) of IKBKAP
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.59 Pain Relevance 0
This may mean that the IKAP protein is directly or indirectly involved in cell cycle checkpoint regulation, and the reduced levels of IKAP in FD cells results in abnormal growth of cells.
Regulation (involved) of Gene_expression (levels) of IKAP associated with familial dysautonomia
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.83 Pain Relevance 0
This may mean that the IKAP protein is directly or indirectly involved in cell cycle checkpoint regulation, and the reduced levels of IKAP in FD cells results in abnormal growth of cells.
Regulation (regulation) of Gene_expression (levels) of IKAP associated with familial dysautonomia
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.82 Pain Relevance 0
Our next goal was to assess whether the production of both WT and MU IKBKAP mRNAs can be modulated in our model.
Regulation (modulated) of Gene_expression (production) of IKBKAP
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.56 Pain Relevance 0
To explore the functional consequence of a down-regulated expression of genes involved in cell migration in FD hOE-MSCs compared to control cells, we used the Boyden's chamber assay.
Regulation (regulated) of Gene_expression (expression) of FD associated with familial dysautonomia
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.77 Pain Relevance 0

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