INT351502

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.86
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
Anatomy Link Frequency
leukocytes 2
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 5 98.50 Very High Very High Very High
imagery 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 605 99.92 Very High Very High Very High
Disease 55 85.00 Quite High
Neurodegenerative Disease 5 61.92 Quite High
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Rare Diseases 10 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Embryonic Lethality 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, kinetin has no significant effects on IKBKAP transcript levels in control cells, which likely excludes a potential action of kinetin on IKBKAP transcription.
Positive_regulation (action) of Transcription (transcription) of IKBKAP
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.23 Pain Relevance 0
Furthermore, the total amount of IKBKAP transcripts in FD (WT+MU) remains 3 to 5 times less abundant than WT in controls, which suggests a defect in IKBKAP transcription and/or mRNA stability.
Positive_regulation (stability) of Transcription (transcription) of IKBKAP associated with familial dysautonomia
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.77 Pain Relevance 0
Additionally, hOE-MSCs are an appropriate model for validating the potency of therapeutic agents such as kinetin, a cytokinin that has been shown to increase IKBKAP mRNA and protein expression in FD cell lines and in vivo models [20], [22], [35], [36] as well as in leukocytes of healthy carriers of the FD mutation [37].


Positive_regulation (increase) of Transcription (expression) of IKBKAP in leukocytes associated with familial dysautonomia and potency
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.90 Pain Relevance 0.05
Since FD hOE-MSCs express a significant amount of MU IKBKAP transcript we asked whether induction of sphere formation could modify the WT?
Positive_regulation (-) of Transcription (transcript) of IKBKAP associated with familial dysautonomia
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.44 Pain Relevance 0
The level of IKBKAP mRNA splicing correction increased proportionally to the concentration of kinetin, and the MU transcript almost vanished at 100 ┬ÁM.
Positive_regulation (increased) of Transcription (correction) of IKBKAP
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.51 Pain Relevance 0

General Comments

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